Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients

Turgut Durduran; Chao Zhou; Brian L. Edlow; Guoqiang Yu; Regine Choe; Meeri N. Kim; Brett L. Cucchiara; Mary E. Putt; Qaisar Shah; Scott E. Kasner; Joel H. Greenberg; Arjun G. Yodh; John A. Detrey

doi:10.1364/OE.17.003884

Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients

Turgut Durduran
, Chao Zhou
, Brian L. Edlow
, Guoqiang Yu
, Regine Choe
, Meeri N. Kim
, Brett L. Cucchiara
, Mary E. Putt
, Qaisar Shah
, Scott E. Kasner
, Joel H. Greenberg
, Arjun G. Yodh
, John A. Detrey

Research output: Contribution to journal › Article › peer-review

142 Scopus citations

Abstract

"Diffuse correlation spectroscopy" (DCS) is a technology for non-invasive transcranial measurement of cerebral blood flow (CBF) that can be hybridized with "near-infrared spectroscopy" (NIRS). Taken together these methods hold potential for monitoring hemodynamics in stroke patients. We explore the utility of DCS and NIRS to measure effects of head-of-bed (HOB) positioning at 30°, 15°, 0°, -5° and 0° angles in patients with acute ischemic stroke affecting frontal cortex and in controls. HOB positioning significantly altered CBF, oxy-hemoglobin (Hb02) and total-hemoglobin (THC) concentrations. Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere.

Original language	English
Pages (from-to)	3884-3902
Number of pages	19
Journal	Optics Express
Volume	17
Issue number	5
DOIs	https://doi.org/10.1364/OE.17.003884
State	Published - Mar 2 2009

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10.1364/OE.17.003884

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title = "Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients",

abstract = "{"}Diffuse correlation spectroscopy{"} (DCS) is a technology for non-invasive transcranial measurement of cerebral blood flow (CBF) that can be hybridized with {"}near-infrared spectroscopy{"} (NIRS). Taken together these methods hold potential for monitoring hemodynamics in stroke patients. We explore the utility of DCS and NIRS to measure effects of head-of-bed (HOB) positioning at 30°, 15°, 0°, -5° and 0° angles in patients with acute ischemic stroke affecting frontal cortex and in controls. HOB positioning significantly altered CBF, oxy-hemoglobin (Hb02) and total-hemoglobin (THC) concentrations. Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere.",

author = "Turgut Durduran and Chao Zhou and Edlow, \{Brian L.\} and Guoqiang Yu and Regine Choe and Kim, \{Meeri N.\} and Cucchiara, \{Brett L.\} and Putt, \{Mary E.\} and Qaisar Shah and Kasner, \{Scott E.\} and Greenberg, \{Joel H.\} and Yodh, \{Arjun G.\} and Detrey, \{John A.\}",

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doi = "10.1364/OE.17.003884",

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TY - JOUR

T1 - Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients

AU - Durduran, Turgut

AU - Zhou, Chao

AU - Edlow, Brian L.

AU - Yu, Guoqiang

AU - Choe, Regine

AU - Kim, Meeri N.

AU - Cucchiara, Brett L.

AU - Putt, Mary E.

AU - Shah, Qaisar

AU - Kasner, Scott E.

AU - Greenberg, Joel H.

AU - Yodh, Arjun G.

AU - Detrey, John A.

PY - 2009/3/2

Y1 - 2009/3/2

N2 - "Diffuse correlation spectroscopy" (DCS) is a technology for non-invasive transcranial measurement of cerebral blood flow (CBF) that can be hybridized with "near-infrared spectroscopy" (NIRS). Taken together these methods hold potential for monitoring hemodynamics in stroke patients. We explore the utility of DCS and NIRS to measure effects of head-of-bed (HOB) positioning at 30°, 15°, 0°, -5° and 0° angles in patients with acute ischemic stroke affecting frontal cortex and in controls. HOB positioning significantly altered CBF, oxy-hemoglobin (Hb02) and total-hemoglobin (THC) concentrations. Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere.

AB - "Diffuse correlation spectroscopy" (DCS) is a technology for non-invasive transcranial measurement of cerebral blood flow (CBF) that can be hybridized with "near-infrared spectroscopy" (NIRS). Taken together these methods hold potential for monitoring hemodynamics in stroke patients. We explore the utility of DCS and NIRS to measure effects of head-of-bed (HOB) positioning at 30°, 15°, 0°, -5° and 0° angles in patients with acute ischemic stroke affecting frontal cortex and in controls. HOB positioning significantly altered CBF, oxy-hemoglobin (Hb02) and total-hemoglobin (THC) concentrations. Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere.

UR - https://www.scopus.com/pages/publications/61549136428

U2 - 10.1364/OE.17.003884

DO - 10.1364/OE.17.003884

M3 - Article

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AN - SCOPUS:61549136428

SN - 1094-4087

VL - 17

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EP - 3902

JO - Optics Express

JF - Optics Express

IS - 5

ER -

Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients

Abstract

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