Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients

Turgut Durduran; Chao Zhou; Brian L. Edlow; Guoqiang Yu; Regine Choe; Meeri N. Kim; Brett L. Cucchiara; Mary E. Putt; Qaisar Shah; Scott E. Kasner; Joel H. Greenberg; Arjun G. Yodh; John A. Detrey

doi:10.1364/OE.17.003884

Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients

Turgut Durduran, Chao Zhou, Brian L. Edlow, Guoqiang Yu, Regine Choe, Meeri N. Kim, Brett L. Cucchiara, Mary E. Putt, Qaisar Shah, Scott E. Kasner, Joel H. Greenberg, Arjun G. Yodh, John A. Detrey

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141 Scopus citations

Abstract

"Diffuse correlation spectroscopy" (DCS) is a technology for non-invasive transcranial measurement of cerebral blood flow (CBF) that can be hybridized with "near-infrared spectroscopy" (NIRS). Taken together these methods hold potential for monitoring hemodynamics in stroke patients. We explore the utility of DCS and NIRS to measure effects of head-of-bed (HOB) positioning at 30°, 15°, 0°, -5° and 0° angles in patients with acute ischemic stroke affecting frontal cortex and in controls. HOB positioning significantly altered CBF, oxy-hemoglobin (Hb02) and total-hemoglobin (THC) concentrations. Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere.

Original language	English
Pages (from-to)	3884-3902
Number of pages	19
Journal	Optics Express
Volume	17
Issue number	5
DOIs	https://doi.org/10.1364/OE.17.003884
State	Published - Mar 2 2009

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title = "Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients",

abstract = "{"}Diffuse correlation spectroscopy{"} (DCS) is a technology for non-invasive transcranial measurement of cerebral blood flow (CBF) that can be hybridized with {"}near-infrared spectroscopy{"} (NIRS). Taken together these methods hold potential for monitoring hemodynamics in stroke patients. We explore the utility of DCS and NIRS to measure effects of head-of-bed (HOB) positioning at 30°, 15°, 0°, -5° and 0° angles in patients with acute ischemic stroke affecting frontal cortex and in controls. HOB positioning significantly altered CBF, oxy-hemoglobin (Hb02) and total-hemoglobin (THC) concentrations. Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere.",

author = "Turgut Durduran and Chao Zhou and Edlow, \{Brian L.\} and Guoqiang Yu and Regine Choe and Kim, \{Meeri N.\} and Cucchiara, \{Brett L.\} and Putt, \{Mary E.\} and Qaisar Shah and Kasner, \{Scott E.\} and Greenberg, \{Joel H.\} and Yodh, \{Arjun G.\} and Detrey, \{John A.\}",

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doi = "10.1364/OE.17.003884",

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T1 - Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients

AU - Durduran, Turgut

AU - Zhou, Chao

AU - Edlow, Brian L.

AU - Yu, Guoqiang

AU - Choe, Regine

AU - Kim, Meeri N.

AU - Cucchiara, Brett L.

AU - Putt, Mary E.

AU - Shah, Qaisar

AU - Kasner, Scott E.

AU - Greenberg, Joel H.

AU - Yodh, Arjun G.

AU - Detrey, John A.

PY - 2009/3/2

Y1 - 2009/3/2

N2 - "Diffuse correlation spectroscopy" (DCS) is a technology for non-invasive transcranial measurement of cerebral blood flow (CBF) that can be hybridized with "near-infrared spectroscopy" (NIRS). Taken together these methods hold potential for monitoring hemodynamics in stroke patients. We explore the utility of DCS and NIRS to measure effects of head-of-bed (HOB) positioning at 30°, 15°, 0°, -5° and 0° angles in patients with acute ischemic stroke affecting frontal cortex and in controls. HOB positioning significantly altered CBF, oxy-hemoglobin (Hb02) and total-hemoglobin (THC) concentrations. Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere.

AB - "Diffuse correlation spectroscopy" (DCS) is a technology for non-invasive transcranial measurement of cerebral blood flow (CBF) that can be hybridized with "near-infrared spectroscopy" (NIRS). Taken together these methods hold potential for monitoring hemodynamics in stroke patients. We explore the utility of DCS and NIRS to measure effects of head-of-bed (HOB) positioning at 30°, 15°, 0°, -5° and 0° angles in patients with acute ischemic stroke affecting frontal cortex and in controls. HOB positioning significantly altered CBF, oxy-hemoglobin (Hb02) and total-hemoglobin (THC) concentrations. Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere.

UR - https://www.scopus.com/pages/publications/61549136428

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DO - 10.1364/OE.17.003884

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VL - 17

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IS - 5

ER -

Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients

Abstract

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