TY - JOUR
T1 - Transcranial laser Doppler mapping of activation flow coupling of the rat somatosensory cortex
AU - Ances, Beau M.
AU - Detre, John A.
AU - Takahashi, Kazushi
AU - Greenberg, Joel H.
N1 - Funding Information:
This work was supported by MH12078, NS01668, NS33785, NS 32017, American Heart Association Cerebrovascular Student Scholarship, and a grant from the American Heart Association, Southeastern PA Affiliate.
PY - 1998/11/20
Y1 - 1998/11/20
N2 - Signal averaged laser Doppler (LD) through a thinned skull over the rat somatosensory cortex was used to map the spatial and temporal characteristics of activation-flow coupling, the change in regional cerebral blood flow (CBF) due to neuronal activation, in response to electrical forepaw stimulation. The location of maximal changes in amplitude of the LD response was reproducibly recorded at 4-5 mm lateral to Bregma. This location is very similar but slightly posterior and lateral to results obtained from electrophysiological, magnetic resonance imaging (MRI), and optical imaging studies. The latency of the activation-flow coupling (AFC) response was inversely correlated to response amplitude, with shorter latencies at positions of maximal amplitude.
AB - Signal averaged laser Doppler (LD) through a thinned skull over the rat somatosensory cortex was used to map the spatial and temporal characteristics of activation-flow coupling, the change in regional cerebral blood flow (CBF) due to neuronal activation, in response to electrical forepaw stimulation. The location of maximal changes in amplitude of the LD response was reproducibly recorded at 4-5 mm lateral to Bregma. This location is very similar but slightly posterior and lateral to results obtained from electrophysiological, magnetic resonance imaging (MRI), and optical imaging studies. The latency of the activation-flow coupling (AFC) response was inversely correlated to response amplitude, with shorter latencies at positions of maximal amplitude.
KW - Activation-flow coupling
KW - Cerebral blood flow
KW - Laser-Doppler flowmetry
KW - Somatosensory cortex
UR - http://www.scopus.com/inward/record.url?scp=0032553560&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(98)00796-4
DO - 10.1016/S0304-3940(98)00796-4
M3 - Article
C2 - 9857957
AN - SCOPUS:0032553560
SN - 0304-3940
VL - 257
SP - 25
EP - 28
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -