Abstract

Signal averaged laser Doppler (LD) through a thinned skull over the rat somatosensory cortex was used to map the spatial and temporal characteristics of activation-flow coupling, the change in regional cerebral blood flow (CBF) due to neuronal activation, in response to electrical forepaw stimulation. The location of maximal changes in amplitude of the LD response was reproducibly recorded at 4-5 mm lateral to Bregma. This location is very similar but slightly posterior and lateral to results obtained from electrophysiological, magnetic resonance imaging (MRI), and optical imaging studies. The latency of the activation-flow coupling (AFC) response was inversely correlated to response amplitude, with shorter latencies at positions of maximal amplitude.

Original languageEnglish
Pages (from-to)25-28
Number of pages4
JournalNeuroscience Letters
Volume257
Issue number1
DOIs
StatePublished - Nov 20 1998

Keywords

  • Activation-flow coupling
  • Cerebral blood flow
  • Laser-Doppler flowmetry
  • Somatosensory cortex

Fingerprint

Dive into the research topics of 'Transcranial laser Doppler mapping of activation flow coupling of the rat somatosensory cortex'. Together they form a unique fingerprint.

Cite this