Transcatheter aortic valve replacement in patients with pure native aortic valve regurgitation: A systematic review and meta-analysis

Abdullah Haddad, Remy Arwani, Osama Altayar, Tarek Sawas, M. Hassan Murad, Eduardo de Marchena

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


This systematic review and meta-analysis sought to summarize the available evidence on the use of transcatheter aortic valve replacement (TAVR) in patients with Native Aortic Valve Regurgitation (NAVR) and compare outcomes between first and second generation valves. Owing to the improvements in transcatheter heart valve design and procedural success, TAVR has become increasingly performed in broader aortic valve pathologies. We searched Medline, Embase, Cochrane, and Scopus databases from 2007 to 2018 and performed a systematic review on reports with at least 10 patients with aortic valve regurgitation undergoing TAVR procedure. The main outcome of interest was all-cause mortality at 30 days. A total of 638 patients across 12 studies were included. Mean age ranged from 68 to 84. Society of Thoracic Surgeons score ranged from 5.4% to 13.1% and Logistic EuroSCORE ranged from 18.2% to 33%. The incidence rate of all-cause mortality at 30 days was found to be 11% (95% CI 7%-16%; I 2 = 20.86%). All-cause mortality at 30 days for first generation valves had an incidence rate of 15% (95% CI 10%-20%; I 2 = 10%) compared to 7% (95% CI 3%-13%; I 2 = 37%) in second generation valves with subgroup interaction analysis P = 0.059. Device success incidence rate in second generation valves was 92% (95% CI 83%-99%; I 2 = 67%) vs 68% (95% CI 59%-77%; I 2 = 53%) in first generation valves with P = 0.001. TAVR appears to be a feasible treatment choice for NAVR patients at high risk for surgical valve replacement. Second generation valves show promising results in terms of short-term outcomes.

Original languageEnglish
Pages (from-to)159-166
Number of pages8
JournalClinical Cardiology
Issue number1
StatePublished - Jan 2019


  • aortic regurgitation
  • meta-analysis
  • systematic review
  • transcatheter aortic valve replacement


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