Tranexamic acid: Optimal blood loss management in surface replacement arthroplasty

A. Sassoon, D. Nam, R. Jackups, S. R. Johnson, R. M. Nunley, R. L. Barrack

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Aims This study investigated whether the use of tranexamic acid (TXA) decreased blood loss and transfusion related cost following surface replacement arthroplasty (SRA). Methods A retrospective review of patients treated with TXA during a SRA, who did not receive autologous blood (TXA group) was performed. Two comparison groups were established; the first group comprised of patients who donated their own blood pre-operatively (auto group) and the second of patients who did not donate blood pre-operatively (control). Outcomes included transfusions, post-operative haemoglobin (Hgb), complications, and length of post-operative stay. Results Between 2009 and 2013, 150 patients undergoing SRA were identified for inclusion: 51 in the auto, 49 in the control, and 50 in the TXA group. There were no differences in the preoperative Hgb concentrations between groups. The mean post-operative Hgb was 11.3 g/dL (9.1 to 13.6) in the auto and TXA groups, and 10.6 g/dL (8.1 to 12.1)in the control group (p = 0.001). Accounting for cost of transfusions, administration of TXA, and length of stay, the cost per patient was $1731, $339, and $185 for the auto, control and TXA groups, respectively. Discussion TXA use demonstrated higher post-operative Hgb concentrations when compared with controls and decreased peri-operative costs.

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalBone and Joint Journal
Issue number2
StatePublished - Feb 2016


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