Trajectories of cortical surface area and cortical volume maturation in normal brain development

for the Brain Development Cooperative Group, Kelly Botteron, Robert C. McKinstry, William Warren, Tomoyuki Nishino, C. Robert Almli, Richard Todd, John Constantino

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


This is a report of developmental trajectories of cortical surface area and cortical volume in the NIH MRI Study of Normal Brain Development. The quality-controlled sample included 384 individual typically-developing subjects with repeated scanning (1-3 per subject, total scans n=753) from 4.9 to 22.3 years of age. The best-fit model (cubic, quadratic, or first-order linear) was identified at each vertex using mixed-effects models, with statistical correction for multiple comparisons using random field theory. Analyses were performed with and without controlling for total brain volume. These data are provided for reference and comparison with other databases. Further discussion and interpretation on cortical developmental trajectories can be found in the associated Ducharme et al.[U+05F3]s article "Trajectories of cortical thickness maturation in normal brain development - the importance of quality control procedures" (Ducharme et al., 2015) [1].

Original languageEnglish
Pages (from-to)929-938
Number of pages10
JournalData in Brief
StatePublished - Dec 1 2015


  • Brain development
  • Cortical surface area
  • Cortical thickness
  • Cortical volume
  • Imaging
  • Magnetic resonance


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