TY - JOUR
T1 - Tractography analysis of 5 white matter bundles and their clinical and cognitive correlates in early-course schizophrenia
AU - Seitz, Johanna
AU - Zuo, Jessica X.
AU - Lyall, Amanda E.
AU - Makris, Nikos
AU - Kikinis, Zora
AU - Bouix, Sylvain
AU - Pasternak, Ofer
AU - Fredman, Eli
AU - Duskin, Jonathan
AU - Goldstein, Jill M.
AU - Petryshen, Tracey L.
AU - Mesholam-Gately, Raquelle I.
AU - Wojcik, Joanne
AU - Mccarley, Robert W.
AU - Seidman, Larry J.
AU - Shenton, Martha E.
AU - Koerte, Inga K.
AU - Kubicki, Marek
N1 - Publisher Copyright:
© The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Purpose: Tractography is the most anatomically accurate method for delineating white matter tracts in the brain, yet few studies have examined multiple tracts using tractography in patients with schizophrenia (SCZ). We analyze 5 white matter connections important in the pathophysiology of SCZ: uncinate fasciculus, cingulum bundle (CB), inferior longitudinal fasciculus (ILF), superior longitudinal fasciculus, and arcuate fasciculus (AF). Additionally, we investigate the relationship between diffusion tensor imaging (DTI) markers and neuropsychological measures. Methods: High-resolution DTI data were acquired on a 3 Tesla scanner in 30 patients with early-course SCZ and 30 healthy controls (HC) from the Boston Center for Intervention Development and Applied Research study. After manually guided tracts delineation, fractional anisotropy (FA), trace, radial diffusivity (RD), and axial diffusivity (AD) were calculated and averaged along each tract. The association of DTI measures with the Scales for the Assessment of Negative and Positive Symptoms and neuropsychological measures was evaluated. Results: Compared to HC, patients exhibited reduced FA and increased trace and RD in the right AF, CB, and ILF. A discriminant analysis showed the possible use of FA of these tracts for better future group membership classifications. FA and RD of the right ILF and AF were associated with positive symptoms while FA and RD of the right CB were associated with memory performance and processing speed. Conclusion: We observed white matter alterations in the right CB, ILF, and AF, possibly caused by myelin disruptions. The structural abnormalities interact with cognitive performance, and are linked to clinical symptoms.
AB - Purpose: Tractography is the most anatomically accurate method for delineating white matter tracts in the brain, yet few studies have examined multiple tracts using tractography in patients with schizophrenia (SCZ). We analyze 5 white matter connections important in the pathophysiology of SCZ: uncinate fasciculus, cingulum bundle (CB), inferior longitudinal fasciculus (ILF), superior longitudinal fasciculus, and arcuate fasciculus (AF). Additionally, we investigate the relationship between diffusion tensor imaging (DTI) markers and neuropsychological measures. Methods: High-resolution DTI data were acquired on a 3 Tesla scanner in 30 patients with early-course SCZ and 30 healthy controls (HC) from the Boston Center for Intervention Development and Applied Research study. After manually guided tracts delineation, fractional anisotropy (FA), trace, radial diffusivity (RD), and axial diffusivity (AD) were calculated and averaged along each tract. The association of DTI measures with the Scales for the Assessment of Negative and Positive Symptoms and neuropsychological measures was evaluated. Results: Compared to HC, patients exhibited reduced FA and increased trace and RD in the right AF, CB, and ILF. A discriminant analysis showed the possible use of FA of these tracts for better future group membership classifications. FA and RD of the right ILF and AF were associated with positive symptoms while FA and RD of the right CB were associated with memory performance and processing speed. Conclusion: We observed white matter alterations in the right CB, ILF, and AF, possibly caused by myelin disruptions. The structural abnormalities interact with cognitive performance, and are linked to clinical symptoms.
KW - arcuate fasciculus
KW - cingulum bundle
KW - cognitive impairments
KW - diffusion MRI
KW - inferior longitudinal fasciculus
KW - lateralization
KW - positive symptoms
KW - superior longitudinal fasciculus
KW - uncinate fasciculus
UR - http://www.scopus.com/inward/record.url?scp=84966262777&partnerID=8YFLogxK
U2 - 10.1093/schbul/sbv171
DO - 10.1093/schbul/sbv171
M3 - Article
C2 - 27009248
AN - SCOPUS:84966262777
SN - 0586-7614
VL - 42
SP - 762
EP - 771
JO - Schizophrenia bulletin
JF - Schizophrenia bulletin
IS - 3
ER -