Tracking X-ray microscopy for alveolar dynamics in live intact mice

Soeun Chang; Namseop Kwon; Byung Mook Weon; Jinkyung Kim; Chin Kook Rhee; Han Sung Choi; Yoshiki Kohmura; Masaki Yamamoto; Tetsuya Ishikawa; Jung Ho Je

doi:10.1038/srep01304

Tracking X-ray microscopy for alveolar dynamics in live intact mice

Soeun Chang, Namseop Kwon, Byung Mook Weon, Jinkyung Kim, Chin Kook Rhee, Han Sung Choi, Yoshiki Kohmura, Masaki Yamamoto, Tetsuya Ishikawa, Jung Ho Je

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11 Scopus citations

Abstract

Here we report a tracking X-ray microscopy (TrXM) as a novel methodology by using upper right lung apices alveoli in live intact mice. By enabling tracking of individual alveolar movements during respiration, TrXM identifies alveolar dynamics: individual alveoli in the upper lung apices show a small size increment as 4.9 ± 0.4% (mean ± s.e.m.) during respiration while their shapes look almost invariant. TrXM analysis in alveolar dynamics would be significant for better understanding of alveolar-based diseases, for instance, ventilator induced lung injury (VILI) in acute respiratory distress syndrome (ARDS).

Original language	English
Article number	1304
Journal	Scientific reports
Volume	3
DOIs	https://doi.org/10.1038/srep01304
State	Published - 2013

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10.1038/srep01304

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title = "Tracking X-ray microscopy for alveolar dynamics in live intact mice",

abstract = "Here we report a tracking X-ray microscopy (TrXM) as a novel methodology by using upper right lung apices alveoli in live intact mice. By enabling tracking of individual alveolar movements during respiration, TrXM identifies alveolar dynamics: individual alveoli in the upper lung apices show a small size increment as 4.9 ± 0.4% (mean ± s.e.m.) during respiration while their shapes look almost invariant. TrXM analysis in alveolar dynamics would be significant for better understanding of alveolar-based diseases, for instance, ventilator induced lung injury (VILI) in acute respiratory distress syndrome (ARDS).",

author = "Soeun Chang and Namseop Kwon and Weon, {Byung Mook} and Jinkyung Kim and Rhee, {Chin Kook} and Choi, {Han Sung} and Yoshiki Kohmura and Masaki Yamamoto and Tetsuya Ishikawa and Je, {Jung Ho}",

note = "Funding Information: This research was supported by the Creative Research Initiatives (Functional X-ray Imaging) of MEST/NRF.",

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doi = "10.1038/srep01304",

language = "English",

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T1 - Tracking X-ray microscopy for alveolar dynamics in live intact mice

AU - Chang, Soeun

AU - Kwon, Namseop

AU - Weon, Byung Mook

AU - Kim, Jinkyung

AU - Rhee, Chin Kook

AU - Choi, Han Sung

AU - Kohmura, Yoshiki

AU - Yamamoto, Masaki

AU - Ishikawa, Tetsuya

AU - Je, Jung Ho

N1 - Funding Information: This research was supported by the Creative Research Initiatives (Functional X-ray Imaging) of MEST/NRF.

PY - 2013

Y1 - 2013

N2 - Here we report a tracking X-ray microscopy (TrXM) as a novel methodology by using upper right lung apices alveoli in live intact mice. By enabling tracking of individual alveolar movements during respiration, TrXM identifies alveolar dynamics: individual alveoli in the upper lung apices show a small size increment as 4.9 ± 0.4% (mean ± s.e.m.) during respiration while their shapes look almost invariant. TrXM analysis in alveolar dynamics would be significant for better understanding of alveolar-based diseases, for instance, ventilator induced lung injury (VILI) in acute respiratory distress syndrome (ARDS).

AB - Here we report a tracking X-ray microscopy (TrXM) as a novel methodology by using upper right lung apices alveoli in live intact mice. By enabling tracking of individual alveolar movements during respiration, TrXM identifies alveolar dynamics: individual alveoli in the upper lung apices show a small size increment as 4.9 ± 0.4% (mean ± s.e.m.) during respiration while their shapes look almost invariant. TrXM analysis in alveolar dynamics would be significant for better understanding of alveolar-based diseases, for instance, ventilator induced lung injury (VILI) in acute respiratory distress syndrome (ARDS).

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VL - 3

JO - Scientific reports

JF - Scientific reports

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Tracking X-ray microscopy for alveolar dynamics in live intact mice

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