TY - JOUR
T1 - Tracking regional brain growth up to age 13 in children born term and very preterm
AU - Thompson, Deanne K.
AU - Matthews, Lillian G.
AU - Alexander, Bonnie
AU - Lee, Katherine J.
AU - Kelly, Claire E.
AU - Adamson, Chris L.
AU - Hunt, Rod W.
AU - Cheong, Jeanie L.Y.
AU - Spencer-Smith, Megan
AU - Neil, Jeffrey J.
AU - Seal, Marc L.
AU - Inder, Terrie E.
AU - Doyle, Lex W.
AU - Anderson, Peter J.
N1 - Funding Information:
We would like to thank members of the Victorian Infant Brain Studies (VIBeS) and Developmental Imaging groups at the Murdoch Children’s Research Institute for ideas and support, Michael Kean and Radiographers at the Royal Children’s Hospital for the magnetic resonance images, and the families and children who participated in this study. This study was supported by the Australian National Health and Medical Research Council (NHMRC) (Centre for Clinical Research Excellence 546519; Centre for Research Excellence 1060733; Project Grants 237117, 491209 & 1066555; Senior Research Fellowships 628371 & 1081288 to PJA; Career Development Fellowship 1085754 to DKT, 1141354 to JLYC and 1127984 to KJL; Early Career Fellowship 1012236 to DKT), Program for Interdisciplinary Neuroscience Traveling Fellowship from the Brigham and Women’s Hospital (LGM), US National Institutes of Health HD058056, United Cerebral Palsy Foundation (USA), Leila Y. Mathers Charitable Foundation (USA), the Brown Foundation (USA), Murdoch Children’s Research Institute, the Royal Children’s Hospital, The Royal Children’s Hospital Foundation, Department of Paediatrics, The University of Melbourne and the Victorian Government’s Operational Infrastructure Support Program.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Serial regional brain growth from the newborn period to adolescence has not been described. Here, we measured regional brain growth in 216 very preterm (VP) and 45 full-term (FT) children. Brain MRI was performed at term-equivalent age, 7 and 13 years in 82 regions. Brain volumes increased between term-equivalent and 7 years, with faster growth in the FT than VP group. Perinatal brain abnormality was associated with less increase in brain volume between term-equivalent and 7 years in the VP group. Between 7 and 13 years, volumes were relatively stable, with some subcortical and cortical regions increasing while others reduced. Notably, VP infants continued to lag, with overall brain size generally less than that of FT peers at 13 years. Parieto–frontal growth, mainly between 7 and 13 years in FT children, was associated with higher intelligence at 13 years. This study improves understanding of typical and atypical regional brain growth.
AB - Serial regional brain growth from the newborn period to adolescence has not been described. Here, we measured regional brain growth in 216 very preterm (VP) and 45 full-term (FT) children. Brain MRI was performed at term-equivalent age, 7 and 13 years in 82 regions. Brain volumes increased between term-equivalent and 7 years, with faster growth in the FT than VP group. Perinatal brain abnormality was associated with less increase in brain volume between term-equivalent and 7 years in the VP group. Between 7 and 13 years, volumes were relatively stable, with some subcortical and cortical regions increasing while others reduced. Notably, VP infants continued to lag, with overall brain size generally less than that of FT peers at 13 years. Parieto–frontal growth, mainly between 7 and 13 years in FT children, was associated with higher intelligence at 13 years. This study improves understanding of typical and atypical regional brain growth.
UR - http://www.scopus.com/inward/record.url?scp=85078875491&partnerID=8YFLogxK
U2 - 10.1038/s41467-020-14334-9
DO - 10.1038/s41467-020-14334-9
M3 - Article
C2 - 32019924
AN - SCOPUS:85078875491
VL - 11
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 696
ER -