Tracking plasticity of individual human brains

Understanding how behavior affects human brain organization was the original motivation behind Precision Functional Mapping (PFM), a deep phenotyping approach to human neuroimaging. Here we review the original PFM studies, as well as research investigating the impact of sensory and/or motor deprivation, or disuse, on brain function. Next, we discuss precision functional mapping of brain plasticity, focusing on experiments that tracked casting of the dominant upper extremity with daily resting-state functional MRI scans. Mechanisms that shape brain circuits during early development may persist into adulthood, helping to maintain the organization of disused circuits.