Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

Sheffield COVID-19 Genomics Group, Members of Sheffield COVID-19 Genomics Group

Research output: Contribution to journalArticlepeer-review

2217 Scopus citations

Abstract

Korber et al. present evidence that there are now more SARS-CoV-2 viruses circulating in the human population globally that have the G614 form of the Spike protein versus the D614 form that was originally identified from the first human cases in Wuhan, China. Follow-up studies show that patients infected with G614 shed more viral nucleic acid compared with those with D614, and G614-bearing viruses show significantly higher infectious titers in vitro than their D614 counterparts.

Original languageEnglish
Pages (from-to)812-827.e19
JournalCell
Volume182
Issue number4
DOIs
StatePublished - Aug 20 2020

Keywords

  • COVID-19
  • PCR cycle threshold
  • SARS-CoV-2
  • Spike
  • antibody
  • diversity
  • evolution
  • infectivity
  • neutralization
  • pseudovirus

Fingerprint

Dive into the research topics of 'Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus'. Together they form a unique fingerprint.

Cite this