Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface

Frederick B. Shipley; Neil Dani; Huixin Xu; Christopher Deister; Jin Cui; Joshua P. Head; Cameron Sadegh; Ryann M. Fame; Morgan L. Shannon; Vanessa I. Flores; Thomas Kishkovich; Emily Jang; Eric M. Klein; Glenn J. Goldey; Kangmin He; Yong Zhang; Michael J. Holtzman; Tomas Kirchhausen; Claire Wyart; Christopher I. Moore; Mark L. Andermann; Maria K. Lehtinen

doi:10.1016/j.neuron.2020.08.024

Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface

Frederick B. Shipley, Neil Dani, Huixin Xu, Christopher Deister, Jin Cui, Joshua P. Head, Cameron Sadegh, Ryann M. Fame, Morgan L. Shannon, Vanessa I. Flores, Thomas Kishkovich, Emily Jang, Eric M. Klein, Glenn J. Goldey, Kangmin He, Yong Zhang, Michael J. Holtzman, Tomas Kirchhausen, Claire Wyart, Christopher I. MooreMark L. Andermann, Maria K. Lehtinen

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

The choroid plexus is a vital brain barrier and source of cerebrospinal fluid. Using two-photon imaging of choroid plexus epithelium in live explants and in awake mice, Shipley et al. establish a platform for investigating subcellular calcium activity and secretion in epithelial cells and diverse surveillance behaviors in immune cells.

Original language	English
Pages (from-to)	623-639.e10
Journal	Neuron
Volume	108
Issue number	4
DOIs	https://doi.org/10.1016/j.neuron.2020.08.024
State	Published - Nov 25 2020

Keywords

calcium activity
cerebrospinal fluid
choroid plexus
epithelial cells
immune cells
secretion
serotonin
two-photon imaging

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10.1016/j.neuron.2020.08.024

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Shipley, F. B., Dani, N., Xu, H., Deister, C., Cui, J., Head, J. P., Sadegh, C., Fame, R. M., Shannon, M. L., Flores, V. I., Kishkovich, T., Jang, E., Klein, E. M., Goldey, G. J., He, K., Zhang, Y., Holtzman, M. J., Kirchhausen, T., Wyart, C., ... Lehtinen, M. K. (2020). Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface. Neuron, 108(4), 623-639.e10. https://doi.org/10.1016/j.neuron.2020.08.024

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title = "Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface",

abstract = "The choroid plexus is a vital brain barrier and source of cerebrospinal fluid. Using two-photon imaging of choroid plexus epithelium in live explants and in awake mice, Shipley et al. establish a platform for investigating subcellular calcium activity and secretion in epithelial cells and diverse surveillance behaviors in immune cells.",

keywords = "calcium activity, cerebrospinal fluid, choroid plexus, epithelial cells, immune cells, secretion, serotonin, two-photon imaging",

author = "Shipley, {Frederick B.} and Neil Dani and Huixin Xu and Christopher Deister and Jin Cui and Head, {Joshua P.} and Cameron Sadegh and Fame, {Ryann M.} and Shannon, {Morgan L.} and Flores, {Vanessa I.} and Thomas Kishkovich and Emily Jang and Klein, {Eric M.} and Goldey, {Glenn J.} and Kangmin He and Yong Zhang and Holtzman, {Michael J.} and Tomas Kirchhausen and Claire Wyart and Moore, {Christopher I.} and Andermann, {Mark L.} and Lehtinen, {Maria K.}",

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year = "2020",

month = nov,

day = "25",

doi = "10.1016/j.neuron.2020.08.024",

language = "English",

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Shipley, FB, Dani, N, Xu, H, Deister, C, Cui, J, Head, JP, Sadegh, C, Fame, RM, Shannon, ML, Flores, VI, Kishkovich, T, Jang, E, Klein, EM, Goldey, GJ, He, K, Zhang, Y , Holtzman, MJ, Kirchhausen, T, Wyart, C, Moore, CI, Andermann, ML & Lehtinen, MK 2020, 'Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface', Neuron, vol. 108, no. 4, pp. 623-639.e10. https://doi.org/10.1016/j.neuron.2020.08.024

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T1 - Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface

AU - Shipley, Frederick B.

AU - Dani, Neil

AU - Xu, Huixin

AU - Deister, Christopher

AU - Cui, Jin

AU - Head, Joshua P.

AU - Sadegh, Cameron

AU - Fame, Ryann M.

AU - Shannon, Morgan L.

AU - Flores, Vanessa I.

AU - Kishkovich, Thomas

AU - Jang, Emily

AU - Klein, Eric M.

AU - Goldey, Glenn J.

AU - He, Kangmin

AU - Zhang, Yong

AU - Holtzman, Michael J.

AU - Kirchhausen, Tomas

AU - Wyart, Claire

AU - Moore, Christopher I.

AU - Andermann, Mark L.

AU - Lehtinen, Maria K.

PY - 2020/11/25

Y1 - 2020/11/25

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KW - calcium activity

KW - cerebrospinal fluid

KW - choroid plexus

KW - epithelial cells

KW - immune cells

KW - secretion

KW - serotonin

KW - two-photon imaging

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DO - 10.1016/j.neuron.2020.08.024

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SP - 623-639.e10

JO - Neuron

JF - Neuron

IS - 4

ER -

Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface

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