Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface

Frederick B. Shipley, Neil Dani, Huixin Xu, Christopher Deister, Jin Cui, Joshua P. Head, Cameron Sadegh, Ryann M. Fame, Morgan L. Shannon, Vanessa I. Flores, Thomas Kishkovich, Emily Jang, Eric M. Klein, Glenn J. Goldey, Kangmin He, Yong Zhang, Michael J. Holtzman, Tomas Kirchhausen, Claire Wyart, Christopher I. MooreMark L. Andermann, Maria K. Lehtinen

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The choroid plexus is a vital brain barrier and source of cerebrospinal fluid. Using two-photon imaging of choroid plexus epithelium in live explants and in awake mice, Shipley et al. establish a platform for investigating subcellular calcium activity and secretion in epithelial cells and diverse surveillance behaviors in immune cells.

Original languageEnglish
Pages (from-to)623-639.e10
JournalNeuron
Volume108
Issue number4
DOIs
StatePublished - Nov 25 2020

Keywords

  • calcium activity
  • cerebrospinal fluid
  • choroid plexus
  • epithelial cells
  • immune cells
  • secretion
  • serotonin
  • two-photon imaging

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