TY - JOUR
T1 - TP53 mutations and lung cancer
T2 - Not all mutations are created equal
AU - Govindan, Ramaswamy
AU - Weber, Jason
N1 - Publisher Copyright:
© 2014 AACR.
PY - 2014
Y1 - 2014
N2 - Mutations in TP53 are common in non-small cell lung cancer. Apart from the loss of tumor-suppressor functions, TP53 mutations may result in gain of function favoring cellular proliferation, inhibition of apoptosis, and genomic instability. Some TP53 mutations are more likely to affect the course of the disease than others.
AB - Mutations in TP53 are common in non-small cell lung cancer. Apart from the loss of tumor-suppressor functions, TP53 mutations may result in gain of function favoring cellular proliferation, inhibition of apoptosis, and genomic instability. Some TP53 mutations are more likely to affect the course of the disease than others.
UR - http://www.scopus.com/inward/record.url?scp=84936136199&partnerID=8YFLogxK
U2 - 10.1158/1078-0432.CCR-14-0899
DO - 10.1158/1078-0432.CCR-14-0899
M3 - Article
C2 - 24916693
AN - SCOPUS:84936136199
SN - 1078-0432
VL - 20
SP - 4419
EP - 4421
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 17
ER -