Mutations in TP53 are common in non-small cell lung cancer. Apart from the loss of tumor-suppressor functions, TP53 mutations may result in gain of function favoring cellular proliferation, inhibition of apoptosis, and genomic instability. Some TP53 mutations are more likely to affect the course of the disease than others.

Original languageEnglish
Pages (from-to)4419-4421
Number of pages3
JournalClinical Cancer Research
Issue number17
StatePublished - 2014


Dive into the research topics of 'TP53 mutations and lung cancer: Not all mutations are created equal'. Together they form a unique fingerprint.

Cite this