TY - JOUR
T1 - Toxicity Profile of Intensity-Modulated Radiation Therapy for Head and Neck Carcinoma and Potential Role of Amifostine
AU - Chao, K. S.Clifford
AU - Ozyigit, Gokhan
AU - Thorsdad, Wade L.
PY - 2003/12
Y1 - 2003/12
N2 - Organ function preservation in patients with head and neck cancer can be achieved by intensity-modulated radiation therapy (IMRT). Much of the work on the physics of IMRT has been done for currently available IMRT systems. However, clinical data remain scarce. Before IMRT is accepted as a standard of care, more comprehensive clinical data on the outcomes of IMRT are needed to substantiate its superiority and advantages over conventional modes of radiotherapy. Concomitant chemoradiation and altered fractionation schemes improve local-regional control, but at the cost of increased toxicity. This article presents a 3-year update of the toxicity profile and therapeutic outcomes of 126 patients with head and neck carcinoma treated with IMRT. An ongoing trial of concomitant chemotherapy and IMRT with subcutaneous amifostine (Ethyol, WR-2721; MedImmune, Inc, Gaithersburg, MD) for organ function preservation is also discussed.
AB - Organ function preservation in patients with head and neck cancer can be achieved by intensity-modulated radiation therapy (IMRT). Much of the work on the physics of IMRT has been done for currently available IMRT systems. However, clinical data remain scarce. Before IMRT is accepted as a standard of care, more comprehensive clinical data on the outcomes of IMRT are needed to substantiate its superiority and advantages over conventional modes of radiotherapy. Concomitant chemoradiation and altered fractionation schemes improve local-regional control, but at the cost of increased toxicity. This article presents a 3-year update of the toxicity profile and therapeutic outcomes of 126 patients with head and neck carcinoma treated with IMRT. An ongoing trial of concomitant chemotherapy and IMRT with subcutaneous amifostine (Ethyol, WR-2721; MedImmune, Inc, Gaithersburg, MD) for organ function preservation is also discussed.
UR - https://www.scopus.com/pages/publications/1642476545
U2 - 10.1053/j.seminoncol.2003.11.009
DO - 10.1053/j.seminoncol.2003.11.009
M3 - Article
C2 - 14727250
AN - SCOPUS:1642476545
SN - 0093-7754
VL - 30
SP - 101
EP - 108
JO - Seminars in Oncology
JF - Seminars in Oncology
IS - 6 SUPPL. 18
ER -