TY - JOUR
T1 - Towards translation of surface-enhanced Raman spectroscopy (SERS) to clinical practice
T2 - Progress and trends
AU - Panikar, Sandeep Surendra
AU - Cialla-May, Dana
AU - De la Rosa, Elder
AU - Salas, Pedro
AU - Popp, Jürgen
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/1
Y1 - 2021/1
N2 - Surface-enhanced Raman spectroscopy (SERS) has demonstrated potential for various biomedical applications. However, when these sensors/substrates are exposed for analysis of complex biological fluids, their sensitivity is gradually decreased due to fouling of proteins on the plasmonic substrates, leading to hotspot blockade. To overcome this limitation, immense efforts have been devoted in recent times to develop stealth SERS substrates to maintain sensing capabilities in clinical samples. Two important methods have been proposed for developing stealth SERS with the use of zwitterionic molecules and nanoshearing force. These stealth modification strategies help reduce the background noise and enhance the sensing capability with their antifouling features for point-of-care-testing (POCT). Additionally, we have highlighted some of the recent SERS developments that demonstrate reliable stealth and sensitivity when employed for diagnosis or personalized treatment. Herein, we concisely review and discuss the future of SERS for investigations in complex clinical samples.
AB - Surface-enhanced Raman spectroscopy (SERS) has demonstrated potential for various biomedical applications. However, when these sensors/substrates are exposed for analysis of complex biological fluids, their sensitivity is gradually decreased due to fouling of proteins on the plasmonic substrates, leading to hotspot blockade. To overcome this limitation, immense efforts have been devoted in recent times to develop stealth SERS substrates to maintain sensing capabilities in clinical samples. Two important methods have been proposed for developing stealth SERS with the use of zwitterionic molecules and nanoshearing force. These stealth modification strategies help reduce the background noise and enhance the sensing capability with their antifouling features for point-of-care-testing (POCT). Additionally, we have highlighted some of the recent SERS developments that demonstrate reliable stealth and sensitivity when employed for diagnosis or personalized treatment. Herein, we concisely review and discuss the future of SERS for investigations in complex clinical samples.
KW - Anti-fouling
KW - Biological fluids
KW - Biomarker
KW - Personalized treatment
KW - Point-of-care-testing (POCT)
KW - Stealth SERS
KW - Surface enhanced Raman spectroscopy (SERS)
KW - Therapeutic drug monitoring (TDM)
KW - Tunable alternating current electrohydrodynamic force (ac-EHD)
KW - Zwitterion
UR - https://www.scopus.com/pages/publications/85097055107
U2 - 10.1016/j.trac.2020.116122
DO - 10.1016/j.trac.2020.116122
M3 - Review article
AN - SCOPUS:85097055107
SN - 0165-9936
VL - 134
JO - TrAC - Trends in Analytical Chemistry
JF - TrAC - Trends in Analytical Chemistry
M1 - 116122
ER -