Towards spatial frequency domain optical imaging of neurovascular coupling in a mouse model of Alzheimer's disease

Alexander J. Lin, Soren D. Konecky, Tyler B. Rice, Kim N. Green, Bernard Choi, Anthony J. Durkin, Bruce J. Tromberg

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Early neurovascular coupling (NVC) changes in Alzheimer's disease can potentially provide imaging biomarkers to assist with diagnosis and treatment. Previous efforts to quantify NVC with intrinsic signal imaging have required assumptions of baseline optical pathlength to calculate changes in oxy- and deoxy-hemoglobin concentrations during evoked stimuli. In this work, we present an economical spatial frequency domain imaging (SFDI) platform utilizing a commercially available LED projector, camera, and off-the-shelf optical components suitable for imaging dynamic optical properties. The fast acquisition platform described in this work is validated on silicone phantoms and demonstrated in neuroimaging of a mouse model.

Original languageEnglish
Title of host publicationPhotonic Therapeutics and Diagnostics VIII
DOIs
StatePublished - 2012
EventPhotonic Therapeutics and Diagnostics VIII - San Francisco, CA, United States
Duration: Jan 21 2012Jan 24 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8207
ISSN (Print)1605-7422

Conference

ConferencePhotonic Therapeutics and Diagnostics VIII
Country/TerritoryUnited States
CitySan Francisco, CA
Period01/21/1201/24/12

Keywords

  • LED microprojector
  • Optical properties

Fingerprint

Dive into the research topics of 'Towards spatial frequency domain optical imaging of neurovascular coupling in a mouse model of Alzheimer's disease'. Together they form a unique fingerprint.

Cite this