Toward a hyperstructure taxonomy

Vic Norris, Tanneke Den Blaauwen, Roy H. Doi, Rasika M. Harshey, Laurent Janniere, Alfonso Jiménez-Sánchez, Jun Jin Ding, Petra Anne Levin, Eugenia Mileykovskaya, Abraham Minsky, Gradimir Misevic, Camille Ripoll, Milton Saier, Kirsten Skarstad, Michel Thellier

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations

Abstract

Bacterial cells contain many large, spatially extended assemblies of ions, molecules, and macromolecules, called hyperstructures, that are implicated in functions that range from DNA replication and cell division to chemotaxis and secretion. Interactions between these hyperstructures would create a level of organization intermediate between macromolecules and the cell itself. To explore this level, a taxonomy is needed. Here, we describe classification criteria based on the form of the hyperstructure and on the processes responsible for this form. These processes include those dependent on coupled transcription-translation, protein-protein affinities, chromosome site-binding by protein, and membrane structures. Various combinations of processes determine the formation, maturation, and demise of many hyperstructures that therefore follow a trajectory within the space of classification by form/process. Hence a taxonomy by trajectory may be desirable. Finally, we suggest that working toward a taxonomy based on speculative interactions between hyperstructures promises most insight into life at this level.

Original languageEnglish
Pages (from-to)309-329
Number of pages21
JournalAnnual review of microbiology
Volume61
DOIs
StatePublished - 2007

Keywords

  • Assembly
  • Bacteria
  • Cell cycle
  • Cytoskeleton
  • Module

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