TY - JOUR
T1 - Total Vitamin D Intake and Risks of Early-Onset Colorectal Cancer and Precursors
AU - Kim, Hanseul
AU - Lipsyc-Sharf, Marla
AU - Zong, Xiaoyu
AU - Wang, Xiaoyan
AU - Hur, Jinhee
AU - Song, Mingyang
AU - Wang, Molin
AU - Smith-Warner, Stephanie A.
AU - Fuchs, Charles
AU - Ogino, Shuji
AU - Wu, Kana
AU - Chan, Andrew T.
AU - Cao, Yin
AU - Ng, Kimmie
AU - Giovannucci, Edward L.
N1 - Publisher Copyright:
© 2021 AGA Institute
PY - 2021/10
Y1 - 2021/10
N2 - Background & Aims: Vitamin D has been implicated in colorectal cancer (CRC) pathogenesis, but it remains unknown whether total vitamin D intake is associated with early-onset CRC and precursors diagnosed before age 50. Methods: We prospectively examined the association between total vitamin D intake and risks of early-onset CRC and precursors among women enrolled in the Nurses’ Health Study II. Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for early-onset CRC were estimated with Cox proportional hazards model. Multivariable-adjusted odds ratios (ORs) and 95% CIs for early-onset conventional adenoma and serrated polyp were estimated with logistic regression model. Results: We documented 111 incident cases of early-onset CRC during 1,250,560 person-years of follow-up (1991 to 2015). Higher total vitamin D intake was significantly associated with a reduced risk of early-onset CRC (HR for ≥450 IU/day vs <300 IU/day, 0.49; 95% CI, 0.26–0.93; P for trend = .01). The HR per 400 IU/day increase was 0.46 (95% CI, 0.26–0.83). The inverse association was significant and appeared more evident for dietary sources of vitamin D (HR per 400 IU/day increase, 0.34; 95% CI, 0.15–0.79) than supplemental vitamin D (HR per 400 IU/day increase, 0.77; 95% CI, 0.37–1.62). For CRC precursors, the ORs per 400 IU/day increase were 0.76 (95% CI, 0.65–0.88) for conventional adenoma (n = 1,439) and 0.85 (95% CI, 0.75–0.97) for serrated polyp (n = 1,878). Conclusions: In a cohort of younger women, higher total vitamin D intake was associated with decreased risks of early-onset CRC and precursors.
AB - Background & Aims: Vitamin D has been implicated in colorectal cancer (CRC) pathogenesis, but it remains unknown whether total vitamin D intake is associated with early-onset CRC and precursors diagnosed before age 50. Methods: We prospectively examined the association between total vitamin D intake and risks of early-onset CRC and precursors among women enrolled in the Nurses’ Health Study II. Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for early-onset CRC were estimated with Cox proportional hazards model. Multivariable-adjusted odds ratios (ORs) and 95% CIs for early-onset conventional adenoma and serrated polyp were estimated with logistic regression model. Results: We documented 111 incident cases of early-onset CRC during 1,250,560 person-years of follow-up (1991 to 2015). Higher total vitamin D intake was significantly associated with a reduced risk of early-onset CRC (HR for ≥450 IU/day vs <300 IU/day, 0.49; 95% CI, 0.26–0.93; P for trend = .01). The HR per 400 IU/day increase was 0.46 (95% CI, 0.26–0.83). The inverse association was significant and appeared more evident for dietary sources of vitamin D (HR per 400 IU/day increase, 0.34; 95% CI, 0.15–0.79) than supplemental vitamin D (HR per 400 IU/day increase, 0.77; 95% CI, 0.37–1.62). For CRC precursors, the ORs per 400 IU/day increase were 0.76 (95% CI, 0.65–0.88) for conventional adenoma (n = 1,439) and 0.85 (95% CI, 0.75–0.97) for serrated polyp (n = 1,878). Conclusions: In a cohort of younger women, higher total vitamin D intake was associated with decreased risks of early-onset CRC and precursors.
KW - Cancer Epidemiology
KW - Colorectal Adenoma
KW - Colorectal Cancer
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=85112063801&partnerID=8YFLogxK
U2 - 10.1053/j.gastro.2021.07.002
DO - 10.1053/j.gastro.2021.07.002
M3 - Article
C2 - 34245763
AN - SCOPUS:85112063801
SN - 0016-5085
VL - 161
SP - 1208-1217.e9
JO - Gastroenterology
JF - Gastroenterology
IS - 4
ER -