Total percentage body weight changes during add-on therapy with tiagabine, carbamazepine and phenytoin

Robert E. Hogan, Mary E. Bertrand, Roger L. Deaton, Kenneth W. Sommerville

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Changes in body weight were evaluated in 349 patients from a study comparing efficacy of add-on therapy with tiagabine (TGB), carbamazepine (CBZ) or phenytoin (PHT). TGB add-on therapy showed no significant weight changes when added to either PHT or CBZ. CBZ add-on therapy showed a significant percentage weight gain of a mean body increase of 1.5% (P = 0.002). Adjunctive TGB therapy had no significant effect on total body weight, while adjunctive CBZ therapy was associated with weight gain. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalEpilepsy Research
Volume41
Issue number1
DOIs
StatePublished - Aug 1 2000

Keywords

  • Antiepileptic drugs
  • Carbamazepine
  • Epilepsy
  • Tiagabine
  • Total body weight

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