Total percentage body weight changes during add-on therapy with tiagabine, carbamazepine and phenytoin

Robert E. Hogan; Mary E. Bertrand; Roger L. Deaton; Kenneth W. Sommerville

doi:10.1016/S0920-1211(00)00125-X

Total percentage body weight changes during add-on therapy with tiagabine, carbamazepine and phenytoin

Robert E. Hogan, Mary E. Bertrand, Roger L. Deaton, Kenneth W. Sommerville

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Changes in body weight were evaluated in 349 patients from a study comparing efficacy of add-on therapy with tiagabine (TGB), carbamazepine (CBZ) or phenytoin (PHT). TGB add-on therapy showed no significant weight changes when added to either PHT or CBZ. CBZ add-on therapy showed a significant percentage weight gain of a mean body increase of 1.5% (P = 0.002). Adjunctive TGB therapy had no significant effect on total body weight, while adjunctive CBZ therapy was associated with weight gain. (C) 2000 Elsevier Science B.V.

Original language	English
Pages (from-to)	23-28
Number of pages	6
Journal	Epilepsy Research
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/S0920-1211(00)00125-X
State	Published - Aug 1 2000

Keywords

Antiepileptic drugs
Carbamazepine
Epilepsy
Tiagabine
Total body weight

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10.1016/S0920-1211(00)00125-X

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AU - Deaton, Roger L.

AU - Sommerville, Kenneth W.

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AB - Changes in body weight were evaluated in 349 patients from a study comparing efficacy of add-on therapy with tiagabine (TGB), carbamazepine (CBZ) or phenytoin (PHT). TGB add-on therapy showed no significant weight changes when added to either PHT or CBZ. CBZ add-on therapy showed a significant percentage weight gain of a mean body increase of 1.5% (P = 0.002). Adjunctive TGB therapy had no significant effect on total body weight, while adjunctive CBZ therapy was associated with weight gain. (C) 2000 Elsevier Science B.V.

KW - Antiepileptic drugs

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KW - Epilepsy

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Total percentage body weight changes during add-on therapy with tiagabine, carbamazepine and phenytoin

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Keywords

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