TY - JOUR
T1 - Total Aortic Replacement in Loeys-Dietz Syndrome
AU - Rankin, J. Scott
AU - Braverman, Alan C.
AU - Kouchoukos, Nicholas T.
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009/6
Y1 - 2009/6
N2 - Loeys-Dietz syndrome presents early in life with rapidly progressive aortic aneurysmal disease, hypertelorism, and bifid uvula/cleft palate. Genetic testing reveals transforming growth factor-β 1 and 2 mutations. Patients require monitoring for progressive aneurysmal disease, and may need total aortic replacement. Two patients are presented who typify these concepts.
AB - Loeys-Dietz syndrome presents early in life with rapidly progressive aortic aneurysmal disease, hypertelorism, and bifid uvula/cleft palate. Genetic testing reveals transforming growth factor-β 1 and 2 mutations. Patients require monitoring for progressive aneurysmal disease, and may need total aortic replacement. Two patients are presented who typify these concepts.
UR - http://www.scopus.com/inward/record.url?scp=65649152332&partnerID=8YFLogxK
U2 - 10.1016/j.athoracsur.2008.10.049
DO - 10.1016/j.athoracsur.2008.10.049
M3 - Article
C2 - 19463636
AN - SCOPUS:65649152332
SN - 0003-4975
VL - 87
SP - 1949
EP - 1951
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 6
ER -