Total Aortic Replacement in Loeys-Dietz Syndrome

J. Scott Rankin, Alan C. Braverman, Nicholas T. Kouchoukos

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Loeys-Dietz syndrome presents early in life with rapidly progressive aortic aneurysmal disease, hypertelorism, and bifid uvula/cleft palate. Genetic testing reveals transforming growth factor-β 1 and 2 mutations. Patients require monitoring for progressive aneurysmal disease, and may need total aortic replacement. Two patients are presented who typify these concepts.

Original languageEnglish
Pages (from-to)1949-1951
Number of pages3
JournalAnnals of Thoracic Surgery
Issue number6
StatePublished - Jun 2009


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