Topical use of recombinant human thrombin for operative hemostasis

Christopher D. Anderson, Lyndsey J. Bowman, William C. Chapman

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Background: The topical use of thrombin has a long history in surgery as an adjunct for achieving operative hemostasis. Until recently the majority of thrombin used topically was derived from bovine plasma. This preparation has been proven to be immunogenic and has led to safety concerns in recent years. Recombinant human thrombin (rhThrombin) has recently been developed as an alternative for topical use for surgical hemostasis. Objective : To review the clinical safety and efficacy data relating to rhThrombin using bovine-derived thrombin as a comparative standard. Methods:This review summaries recent literature regarding topical use of rhThrombin using bovine thrombin as the 'gold standard' for topical surgical hemostasis. Conclusions:The data indicates that topical rhThrombin is as effective as bovine thrombin for hemostasis and significantly less immunogenic.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalExpert opinion on biological therapy
Issue number1
StatePublished - Jan 2009


  • Antithrombin antibodies
  • Hemostasis
  • Recombinant human thrombin
  • Thrombin


Dive into the research topics of 'Topical use of recombinant human thrombin for operative hemostasis'. Together they form a unique fingerprint.

Cite this