Tomographic images of blood pool and perfusion in brain and heart

M. E. Phelps, E. J. Hoffman, R. E. Coleman, M. J. Welch, M. E. Raichle, E. S. Weiss, B. E. Sobel, M. M. Ter-Pogossian

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

A whole body positron emission transaxial tomograph (PETT III) was used to image the cross sectional distribution of 13NH 3 and 11CO hemoglobin in the human brain and heart. Carotid and intravenous bolus injections of 13NH 3 in the rhesus monkey had shown that 13NH 3 is efficiently extracted by the brain and clears from it slowly (half time, 40-50 min for carotid injections and 60-70 min for intravenous injections). The intravenous tomographic images in humans showed an excellent relationship between 13NH 3 uptakes in the cortex, subcortical white matter, cerebellum, and brain stem and normal blood perfusion or flow in these structures. Cerebral lesions with high (metastasis) and low (stroke) blood flows showed correspondingly high and low uptakes of 13NH 3. Large and small vascular structures of the brain were also clearly seen in 11CO hemoglobin tomographic images. Normal myocardium and the ventricular chambers were well defined, and a transmural anterior myocardial infarct was clearly shown. The effective combination of positron transaxial tomography and compounds labeled with positron emitters provides a safe new method for quantitatively imaging hemodynamic and physiologic functions of selected organs with good tomographic image quality.

Original languageEnglish
Pages (from-to)603-612
Number of pages10
JournalJournal of Nuclear Medicine
Volume17
Issue number7
StatePublished - Dec 1 1976

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