Abstract
Many autoimmune diseases are thought to be precipitated by viral infections. In this issue of the JCI, Lang et al. demonstrate that, in a mouse model of autoimmune hepatitis, viral infections not only trigger expansion of self-reactive T cells but also activate antigen-presenting cells through TLR stimulation (see the related article beginning on page 2456). Activated cells then secrete IFN-α and TNF-α, which trigger tissue release of chemokines that attract self-reactive CD8+ T cells, ultimately leading to liver damage.
Original language | English |
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Pages (from-to) | 2319-2322 |
Number of pages | 4 |
Journal | Journal of Clinical Investigation |
Volume | 116 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1 2006 |