TY - JOUR
T1 - Toll-like receptors and human disease
T2 - Lessons from single nucleotide polymorphisms
AU - Lin, Yi Tzu
AU - Verma, Amanda
AU - Hodgkinson, Conrad P.
PY - 2012
Y1 - 2012
N2 - Toll-like receptors (TLRs), a large group of proteins which recognize various pathogen-associated molecular patterns, are critical for the normal function of the innate immune system. Following their discovery many single nucleotide polymorphisms within TLRs and components of their signaling machinery have been discovered and subsequently implicated in a wide range of human diseases including atherosclerosis, sepsis, asthma, and immunodeficiency. This review discusses the effect of genetic variation on TLR function and how they may precipitate disease.
AB - Toll-like receptors (TLRs), a large group of proteins which recognize various pathogen-associated molecular patterns, are critical for the normal function of the innate immune system. Following their discovery many single nucleotide polymorphisms within TLRs and components of their signaling machinery have been discovered and subsequently implicated in a wide range of human diseases including atherosclerosis, sepsis, asthma, and immunodeficiency. This review discusses the effect of genetic variation on TLR function and how they may precipitate disease.
KW - Atherosclerosis
KW - Genetic association studies
KW - Inflammation
KW - Innate immunity
KW - Single nucleotide polymorphisms
KW - Toll-like receptors
UR - http://www.scopus.com/inward/record.url?scp=84870214884&partnerID=8YFLogxK
U2 - 10.2174/138920212803759712
DO - 10.2174/138920212803759712
M3 - Review article
C2 - 23730203
AN - SCOPUS:84870214884
SN - 1389-2029
VL - 13
SP - 633
EP - 645
JO - Current Genomics
JF - Current Genomics
IS - 8
ER -