Tolerization of dendritic cells by Ts cells: The crucial role of inhibitory receptors ILT3 and ILT4

C. C. Chang, R. Ciubotariu, J. S. Manavalan, J. Yuan, A. I. Colovai, F. Piazza, S. Lederman, M. Colonna, R. Cortesini, R. Dalla-Favera, N. Suciu-Foca

Research output: Contribution to journalArticlepeer-review

687 Scopus citations

Abstract

Immunoglobulin-like transcript 3 (ILT3) and ILT4 belong to a family of inhibitory receptors expressed by human monocytes and dendritic cells. We show here that CD8+CD28 alloantigen-specific T suppressor (Ts) cells induce the up-regulation of ILT3 and ILT4 on monocytes and dendritic cells, rendering these antigen-presenting cells (APCs) tolerogenic. Tolerogenic APCs show reduced expression of costimulatory molecules and induce antigen-specific unresponsiveness in CD4+T helper cells. Studies of human heart transplant recipients showed that rejection-free patients have circulating Ts cells, which induce the up-regulation of ILT3 and ILT4 in donor APCs. These findings demonstrate an important mechanism of immune regulation.

Original languageEnglish
Pages (from-to)237-243
Number of pages7
JournalNature immunology
Volume3
Issue number3
DOIs
StatePublished - Mar 2002

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