Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells

Jeong Hyeon Sohn; Puran S. Bora; Hye Jung Suk; Hector Molina; Henry J. Kaplan; Nalini S. Bora

doi:10.1038/nm814

Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells

Jeong Hyeon Sohn, Puran S. Bora, Hye Jung Suk, Hector Molina, Henry J. Kaplan, Nalini S. Bora

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180 Scopus citations

Abstract

Systemic tolerance can be induced by the introduction of antigen into an immune-privileged site. Here we investigated the role of complement in the induction of tolerance after intraocular injection. We found that the development of antigen-specific tolerance is dependent on a complement activation product. The ligation of the complement C3 activation product iC3b to complement receptor type 3 (the iC3b receptor) on antigen-presenting cells resulted in the sequential production of transforming growth factor-β2 and interleukin-10, which is essential for the induction of tolerance. These observations may extend to the development of both neonatal tolerance and other forms of acquired tolerance.

Original language	English
Pages (from-to)	206-212
Number of pages	7
Journal	Nature medicine
Volume	9
Issue number	2
DOIs	https://doi.org/10.1038/nm814
State	Published - Feb 1 2003

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title = "Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells",

abstract = "Systemic tolerance can be induced by the introduction of antigen into an immune-privileged site. Here we investigated the role of complement in the induction of tolerance after intraocular injection. We found that the development of antigen-specific tolerance is dependent on a complement activation product. The ligation of the complement C3 activation product iC3b to complement receptor type 3 (the iC3b receptor) on antigen-presenting cells resulted in the sequential production of transforming growth factor-β2 and interleukin-10, which is essential for the induction of tolerance. These observations may extend to the development of both neonatal tolerance and other forms of acquired tolerance.",

author = "Sohn, {Jeong Hyeon} and Bora, {Puran S.} and Suk, {Hye Jung} and Hector Molina and Kaplan, {Henry J.} and Bora, {Nalini S.}",

note = "Funding Information: Acknowledgments We thank J.P. Atkinson for critical review of the data and Y. Wang for help with RT–PCR analysis. This work was supported in part by EY09730, EY10543 and EY 13335, Commonwealth of Kentucky Research Challenge Trust Fund and Research to Prevent Blindness Inc., NY.",

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AU - Molina, Hector

AU - Kaplan, Henry J.

AU - Bora, Nalini S.

N1 - Funding Information: Acknowledgments We thank J.P. Atkinson for critical review of the data and Y. Wang for help with RT–PCR analysis. This work was supported in part by EY09730, EY10543 and EY 13335, Commonwealth of Kentucky Research Challenge Trust Fund and Research to Prevent Blindness Inc., NY.

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AB - Systemic tolerance can be induced by the introduction of antigen into an immune-privileged site. Here we investigated the role of complement in the induction of tolerance after intraocular injection. We found that the development of antigen-specific tolerance is dependent on a complement activation product. The ligation of the complement C3 activation product iC3b to complement receptor type 3 (the iC3b receptor) on antigen-presenting cells resulted in the sequential production of transforming growth factor-β2 and interleukin-10, which is essential for the induction of tolerance. These observations may extend to the development of both neonatal tolerance and other forms of acquired tolerance.

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Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells

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