TY - JOUR
T1 - To skip or not to skip
T2 - choosing repriming to tolerate DNA damage
AU - Quinet, Annabel
AU - Tirman, Stephanie
AU - Cybulla, Emily
AU - Meroni, Alice
AU - Vindigni, Alessandro
N1 - Funding Information:
We thank K. Cimprich and Y. Ayala for their careful reading of the manuscript and insightful comments. This work was supported by National Cancer Institute (NCI) grants R01CA237263 (to A.V.) and F30CA254215 (to E.C.). Figures were created using BioRender.com .
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/2/18
Y1 - 2021/2/18
N2 - Replication stress response pathways allow DNA replication to tolerate obstacles with minimal delay in fork elongation. In this review, Quinet et al. discuss the molecular contexts in which cells choose repriming over template switching and translesion synthesis to tolerate these obstacles and the consequences of this choice on genome integrity.
AB - Replication stress response pathways allow DNA replication to tolerate obstacles with minimal delay in fork elongation. In this review, Quinet et al. discuss the molecular contexts in which cells choose repriming over template switching and translesion synthesis to tolerate these obstacles and the consequences of this choice on genome integrity.
UR - http://www.scopus.com/inward/record.url?scp=85100667771&partnerID=8YFLogxK
U2 - 10.1016/j.molcel.2021.01.012
DO - 10.1016/j.molcel.2021.01.012
M3 - Review article
C2 - 33515486
AN - SCOPUS:85100667771
SN - 1097-2765
VL - 81
SP - 649
EP - 658
JO - Molecular cell
JF - Molecular cell
IS - 4
ER -