TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study

MAPT/DSA Group; Kelly Virecoulon Giudici; Philipe de Souto Barreto; Sophie Guyonnet; John E. Morley; Andrew D. Nguyen; Geetika Aggarwal; Angelo Parini; Yan Li; Randall John Bateman; Bruno Vellas; Isabelle Carrié; Lauréane Brigitte; Catherine Faisant; Françoise Lala; Julien Delrieu; Hélène Villars; Emeline Combrouze; Carole Badufle; Audrey Zueras; Sandrine Andrieu; Christelle Cantet; Christophe Morin; Gabor Abellan Van Kan; Charlotte Dupuy; Yves Rolland; Céline Caillaud; Pierre Jean Ousset; Fabrice Bonneville; Christophe Cognard; François Chollet; Pierre Payoux; Thierry Voisin; Sophie Peiffer; Anne Hitzel; Laurent Molinier; Hélène Derumeaux; Nadège Costa; Bertrand Perret; Claire Vinel; Sylvie Caspar-Bauguil; Pascale Olivier-Abbal; Nicola Coley; Sherry Willis; Sylvie Belleville; Brigitte Gilbert; Francine Fontaine; Jean François Dartigues; Isabelle Marcet; Fleur Delva; Alexandra Foubert; Sandrine Cerda; Carole Dufouil; Michèle Allard; Marie-Noëlle-Cuffi; Corinne Costes; Olivier Rouaud; Patrick Manckoundia; Valérie Quipourt; Sophie Marilier; Evelyne Franon; Frédéric Ricolfi; Lawrence Bories; Marie Laure Pader; Marie France Basset; Bruno Lapoujade; Valérie Faure; Michael Li Yung Tong; Christine Malick-Loiseau; Evelyne Cazaban-Campistron; Dominique Dubois; Françoise Desclaux; Colette Blatge; Thierry Dantoine; Cécile Laubarie-Mouret; Isabelle Saulnier; Jean Pierre Clément; Marie Agnès Picat; Laurence Bernard-Bourzeix; Stéphanie Willebois; Iléana Désormais; Noëlle Cardinaud; Marie Paule Bonceour Martel; Jacques Monteil; Marc Bonnefoy; Pierre Livet; Pascale Rebaudet; Claire Gédéon; Catherine Burdet; Flavien Terracol; François Cotton; Alain Pesce; Stéphanie Roth; Sylvie Chaillou; Sandrine Louchart; Kristel Sudres; Nicolas Lebrun; Nadège Barro-Belaygues; Jacques Touchon; Karim Bennys; Audrey Gabelle; Aurélia Romano; Lynda Touati; Cécilia Marelli; Cécile Pays; Alain Bonafé; Michel Zanca; Philippe Robert; Franck Le Duff; Claire Gervais; Sébastien Gonfrier; Stéphane Chanalet; Jacques Darcourt; Yannick Gasnier; Serge Bordes; Danièle Begorre; Christian Carpuat; Khaled Khales; Jean François Lefebvre; Samira Misbah El Idrissi; Pierre Skolil; Jean Pierre Salles; Françoise Hugon; Stéphane Lehéricy; Marie Chupin; Jean François Mangin; Ali Bouhayia

doi:10.1093/gerona/glac244

TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study

MAPT/DSA Group, Kelly Virecoulon Giudici, Philipe de Souto Barreto, Sophie Guyonnet, John E. Morley, Andrew D. Nguyen, Geetika Aggarwal, Angelo Parini, Yan Li, Randall John Bateman, Bruno Vellas, Isabelle Carrié, Lauréane Brigitte, Catherine Faisant, Françoise Lala, Julien Delrieu, Hélène Villars, Emeline Combrouze, Carole Badufle, Audrey ZuerasSandrine Andrieu, Christelle Cantet, Christophe Morin, Gabor Abellan Van Kan, Charlotte Dupuy, Yves Rolland, Céline Caillaud, Pierre Jean Ousset, Fabrice Bonneville, Christophe Cognard, François Chollet, Pierre Payoux, Thierry Voisin, Sophie Peiffer, Anne Hitzel, Laurent Molinier, Hélène Derumeaux, Nadège Costa, Bertrand Perret, Claire Vinel, Sylvie Caspar-Bauguil, Pascale Olivier-Abbal, Nicola Coley, Sherry Willis, Sylvie Belleville, Brigitte Gilbert, Francine Fontaine, Jean François Dartigues, Isabelle Marcet, Fleur Delva, Alexandra Foubert, Sandrine Cerda, Carole Dufouil, Michèle Allard, Marie-Noëlle-Cuffi, Corinne Costes, Olivier Rouaud, Patrick Manckoundia, Valérie Quipourt, Sophie Marilier, Evelyne Franon, Frédéric Ricolfi, Lawrence Bories, Marie Laure Pader, Marie France Basset, Bruno Lapoujade, Valérie Faure, Michael Li Yung Tong, Christine Malick-Loiseau, Evelyne Cazaban-Campistron, Dominique Dubois, Françoise Desclaux, Colette Blatge, Thierry Dantoine, Cécile Laubarie-Mouret, Isabelle Saulnier, Jean Pierre Clément, Marie Agnès Picat, Laurence Bernard-Bourzeix, Stéphanie Willebois, Iléana Désormais, Noëlle Cardinaud, Marie Paule Bonceour Martel, Jacques Monteil, Marc Bonnefoy, Pierre Livet, Pascale Rebaudet, Claire Gédéon, Catherine Burdet, Flavien Terracol, François Cotton, Alain Pesce, Stéphanie Roth, Sylvie Chaillou, Sandrine Louchart, Kristel Sudres, Nicolas Lebrun, Nadège Barro-Belaygues, Jacques Touchon, Karim Bennys, Audrey Gabelle, Aurélia Romano, Lynda Touati, Cécilia Marelli, Cécile Pays, Alain Bonafé, Michel Zanca, Philippe Robert, Franck Le Duff, Claire Gervais, Sébastien Gonfrier, Stéphane Chanalet, Jacques Darcourt, Yannick Gasnier, Serge Bordes, Danièle Begorre, Christian Carpuat, Khaled Khales, Jean François Lefebvre, Samira Misbah El Idrissi, Pierre Skolil, Jean Pierre Salles, Françoise Hugon, Stéphane Lehéricy, Marie Chupin, Jean François Mangin, Ali Bouhayia

Hope Center for Neurological Disorders

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

There is growing evidence that cognitive decline can be affected by both nutritional aspects and inflammation. Plasma neurodegenerative biomarkers stand out as minimally invasive useful measures to monitor the potential risk of cognitive decline. This study aimed to investigate the associations between biomarkers of neurodegeneration, nutrition, and inflammation among community-dwelling older adults, and to verify if associations differed according to apolipoprotein E (APOE) ε4 status. This cross-sectional analysis included 475 participants ≥70 years old from the Multidomain Alzheimer Preventive Trial (MAPT), mean age 76.8 years (SD = 4.5), 59.4% women. Biomarkers of neurodegeneration (plasma amyloid-β_42/40—Aβ_42/40, neurofilament light chain—NfL, progranulin), nutrition (erythrocyte docosahexaenoic acid, eicosapentaenoic acid, omega-3 index; plasma homocysteine—Hcy, 25 hydroxyvitamin D), inflammation (plasma tumor necrosis factor receptor 1—TNFR-1, monocyte chemoattractant protein 1—MCP-1, interleukin 6—IL-6), and cellular stress (plasma growth differentiation factor 15—GDF-15) were assessed. Linear regression analyses were performed to investigate the associations between nutritional and inflammatory biomarkers (independent variables) and neurodegenerative biomarkers (dependent variables), with adjustments for age, sex, education, body mass index, physical activity, allocation to MAPT groups, and APOE ε4 status. After adjusting for confounders, Aβ_42/40 was not associated with nutritional or inflammatory markers. NfL was positively associated with GDF-15, TNFR-1, IL-6, and Hcy. Progranulin was positively associated with GDF-15, TNFR-1, and MCP-1. Analyses restricted to APOE ε4 carriers (n = 116; 26.9%) or noncarriers were mostly similar. Our cross-sectional study with community-dwelling older adults corroborates previous evidence that inflammatory pathways are associated to plasma markers of neurodegeneration.

Original language	English
Pages (from-to)	569-578
Number of pages	10
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	78
Issue number	4
DOIs	https://doi.org/10.1093/gerona/glac244
State	Published - Apr 1 2023

Keywords

Amyloid-β
Cognitive decline
Inflammation
Neurodegeneration
Nutrition

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10.1093/gerona/glac244

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MAPT/DSA Group, Giudici, K. V., Barreto, P. D. S., Guyonnet, S., Morley, J. E., Nguyen, A. D., Aggarwal, G., Parini, A., Li, Y., John Bateman, R., Vellas, B., Carrié, I., Brigitte, L., Faisant, C., Lala, F., Delrieu, J., Villars, H., Combrouze, E., Badufle, C., ... Bouhayia, A. (2023). TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 78(4), 569-578. https://doi.org/10.1093/gerona/glac244

@article{3a42810fa2a046d38a5c7c613d966f00,

title = "TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study",

abstract = "There is growing evidence that cognitive decline can be affected by both nutritional aspects and inflammation. Plasma neurodegenerative biomarkers stand out as minimally invasive useful measures to monitor the potential risk of cognitive decline. This study aimed to investigate the associations between biomarkers of neurodegeneration, nutrition, and inflammation among community-dwelling older adults, and to verify if associations differed according to apolipoprotein E (APOE) ε4 status. This cross-sectional analysis included 475 participants ≥70 years old from the Multidomain Alzheimer Preventive Trial (MAPT), mean age 76.8 years (SD = 4.5), 59.4% women. Biomarkers of neurodegeneration (plasma amyloid-β42/40—Aβ42/40, neurofilament light chain—NfL, progranulin), nutrition (erythrocyte docosahexaenoic acid, eicosapentaenoic acid, omega-3 index; plasma homocysteine—Hcy, 25 hydroxyvitamin D), inflammation (plasma tumor necrosis factor receptor 1—TNFR-1, monocyte chemoattractant protein 1—MCP-1, interleukin 6—IL-6), and cellular stress (plasma growth differentiation factor 15—GDF-15) were assessed. Linear regression analyses were performed to investigate the associations between nutritional and inflammatory biomarkers (independent variables) and neurodegenerative biomarkers (dependent variables), with adjustments for age, sex, education, body mass index, physical activity, allocation to MAPT groups, and APOE ε4 status. After adjusting for confounders, Aβ42/40 was not associated with nutritional or inflammatory markers. NfL was positively associated with GDF-15, TNFR-1, IL-6, and Hcy. Progranulin was positively associated with GDF-15, TNFR-1, and MCP-1. Analyses restricted to APOE ε4 carriers (n = 116; 26.9%) or noncarriers were mostly similar. Our cross-sectional study with community-dwelling older adults corroborates previous evidence that inflammatory pathways are associated to plasma markers of neurodegeneration.",

keywords = "Amyloid-β, Cognitive decline, Inflammation, Neurodegeneration, Nutrition",

author = "{MAPT/DSA Group} and Giudici, {Kelly Virecoulon} and Barreto, {Philipe de Souto} and Sophie Guyonnet and Morley, {John E.} and Nguyen, {Andrew D.} and Geetika Aggarwal and Angelo Parini and Yan Li and {John Bateman}, Randall and Bruno Vellas and Isabelle Carri{\'e} and Laur{\'e}ane Brigitte and Catherine Faisant and Fran{\c c}oise Lala and Julien Delrieu and H{\'e}l{\`e}ne Villars and Emeline Combrouze and Carole Badufle and Audrey Zueras and Sandrine Andrieu and Christelle Cantet and Christophe Morin and {Van Kan}, {Gabor Abellan} and Charlotte Dupuy and Yves Rolland and C{\'e}line Caillaud and Ousset, {Pierre Jean} and Fabrice Bonneville and Christophe Cognard and Fran{\c c}ois Chollet and Pierre Payoux and Thierry Voisin and Sophie Peiffer and Anne Hitzel and Laurent Molinier and H{\'e}l{\`e}ne Derumeaux and Nad{\`e}ge Costa and Bertrand Perret and Claire Vinel and Sylvie Caspar-Bauguil and Pascale Olivier-Abbal and Nicola Coley and Sherry Willis and Sylvie Belleville and Brigitte Gilbert and Francine Fontaine and Dartigues, {Jean Fran{\c c}ois} and Isabelle Marcet and Fleur Delva and Alexandra Foubert and Sandrine Cerda and Carole Dufouil and Mich{\`e}le Allard and Marie-No{\"e}lle-Cuffi and Corinne Costes and Olivier Rouaud and Patrick Manckoundia and Val{\'e}rie Quipourt and Sophie Marilier and Evelyne Franon and Fr{\'e}d{\'e}ric Ricolfi and Lawrence Bories and Pader, {Marie Laure} and Basset, {Marie France} and Bruno Lapoujade and Val{\'e}rie Faure and Tong, {Michael Li Yung} and Christine Malick-Loiseau and Evelyne Cazaban-Campistron and Dominique Dubois and Fran{\c c}oise Desclaux and Colette Blatge and Thierry Dantoine and C{\'e}cile Laubarie-Mouret and Isabelle Saulnier and Cl{\'e}ment, {Jean Pierre} and Picat, {Marie Agn{\`e}s} and Laurence Bernard-Bourzeix and St{\'e}phanie Willebois and Il{\'e}ana D{\'e}sormais and No{\"e}lle Cardinaud and {Bonceour Martel}, {Marie Paule} and Jacques Monteil and Marc Bonnefoy and Pierre Livet and Pascale Rebaudet and Claire G{\'e}d{\'e}on and Catherine Burdet and Flavien Terracol and Fran{\c c}ois Cotton and Alain Pesce and St{\'e}phanie Roth and Sylvie Chaillou and Sandrine Louchart and Kristel Sudres and Nicolas Lebrun and Nad{\`e}ge Barro-Belaygues and Jacques Touchon and Karim Bennys and Audrey Gabelle and Aur{\'e}lia Romano and Lynda Touati and C{\'e}cilia Marelli and C{\'e}cile Pays and Alain Bonaf{\'e} and Michel Zanca and Philippe Robert and {Le Duff}, Franck and Claire Gervais and S{\'e}bastien Gonfrier and St{\'e}phane Chanalet and Jacques Darcourt and Yannick Gasnier and Serge Bordes and Dani{\`e}le Begorre and Christian Carpuat and Khaled Khales and Lefebvre, {Jean Fran{\c c}ois} and {El Idrissi}, {Samira Misbah} and Pierre Skolil and Salles, {Jean Pierre} and Fran{\c c}oise Hugon and St{\'e}phane Leh{\'e}ricy and Marie Chupin and Mangin, {Jean Fran{\c c}ois} and Ali Bouhayia",

year = "2023",

month = apr,

day = "1",

doi = "10.1093/gerona/glac244",

language = "English",

volume = "78",

pages = "569--578",

journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",

issn = "1079-5006",

number = "4",

}

MAPT/DSA Group, Giudici, KV, Barreto, PDS, Guyonnet, S, Morley, JE, Nguyen, AD, Aggarwal, G, Parini, A, Li, Y, John Bateman, R, Vellas, B, Carrié, I, Brigitte, L, Faisant, C, Lala, F, Delrieu, J, Villars, H, Combrouze, E, Badufle, C, Zueras, A, Andrieu, S, Cantet, C, Morin, C, Van Kan, GA, Dupuy, C, Rolland, Y, Caillaud, C, Ousset, PJ, Bonneville, F, Cognard, C, Chollet, F, Payoux, P, Voisin, T, Peiffer, S, Hitzel, A, Molinier, L, Derumeaux, H, Costa, N, Perret, B, Vinel, C, Caspar-Bauguil, S, Olivier-Abbal, P, Coley, N, Willis, S, Belleville, S, Gilbert, B, Fontaine, F, Dartigues, JF, Marcet, I, Delva, F, Foubert, A, Cerda, S, Dufouil, C, Allard, M, Marie-Noëlle-Cuffi, Costes, C, Rouaud, O, Manckoundia, P, Quipourt, V, Marilier, S, Franon, E, Ricolfi, F, Bories, L, Pader, ML, Basset, MF, Lapoujade, B, Faure, V, Tong, MLY, Malick-Loiseau, C, Cazaban-Campistron, E, Dubois, D, Desclaux, F, Blatge, C, Dantoine, T, Laubarie-Mouret, C, Saulnier, I, Clément, JP, Picat, MA, Bernard-Bourzeix, L, Willebois, S, Désormais, I, Cardinaud, N, Bonceour Martel, MP, Monteil, J, Bonnefoy, M, Livet, P, Rebaudet, P, Gédéon, C, Burdet, C, Terracol, F, Cotton, F, Pesce, A, Roth, S, Chaillou, S, Louchart, S, Sudres, K, Lebrun, N, Barro-Belaygues, N, Touchon, J, Bennys, K, Gabelle, A, Romano, A, Touati, L, Marelli, C, Pays, C, Bonafé, A, Zanca, M, Robert, P, Le Duff, F, Gervais, C, Gonfrier, S, Chanalet, S, Darcourt, J, Gasnier, Y, Bordes, S, Begorre, D, Carpuat, C, Khales, K, Lefebvre, JF, El Idrissi, SM, Skolil, P, Salles, JP, Hugon, F, Lehéricy, S, Chupin, M, Mangin, JF & Bouhayia, A 2023, 'TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 78, no. 4, pp. 569-578. https://doi.org/10.1093/gerona/glac244

TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study. / MAPT/DSA Group; Giudici, Kelly Virecoulon; Barreto, Philipe de Souto et al.
In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 78, No. 4, 01.04.2023, p. 569-578.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults

T2 - A Secondary Analysis of the MAPT Study

AU - MAPT/DSA Group

AU - Giudici, Kelly Virecoulon

AU - Barreto, Philipe de Souto

AU - Guyonnet, Sophie

AU - Morley, John E.

AU - Nguyen, Andrew D.

AU - Aggarwal, Geetika

AU - Parini, Angelo

AU - Li, Yan

AU - John Bateman, Randall

AU - Vellas, Bruno

AU - Carrié, Isabelle

AU - Brigitte, Lauréane

AU - Faisant, Catherine

AU - Lala, Françoise

AU - Delrieu, Julien

AU - Villars, Hélène

AU - Combrouze, Emeline

AU - Badufle, Carole

AU - Zueras, Audrey

AU - Andrieu, Sandrine

AU - Cantet, Christelle

AU - Morin, Christophe

AU - Van Kan, Gabor Abellan

AU - Dupuy, Charlotte

AU - Rolland, Yves

AU - Caillaud, Céline

AU - Ousset, Pierre Jean

AU - Bonneville, Fabrice

AU - Cognard, Christophe

AU - Chollet, François

AU - Payoux, Pierre

AU - Voisin, Thierry

AU - Peiffer, Sophie

AU - Hitzel, Anne

AU - Molinier, Laurent

AU - Derumeaux, Hélène

AU - Costa, Nadège

AU - Perret, Bertrand

AU - Vinel, Claire

AU - Caspar-Bauguil, Sylvie

AU - Olivier-Abbal, Pascale

AU - Coley, Nicola

AU - Willis, Sherry

AU - Belleville, Sylvie

AU - Gilbert, Brigitte

AU - Fontaine, Francine

AU - Dartigues, Jean François

AU - Marcet, Isabelle

AU - Delva, Fleur

AU - Foubert, Alexandra

AU - Cerda, Sandrine

AU - Dufouil, Carole

AU - Allard, Michèle

AU - Marie-Noëlle-Cuffi,

AU - Costes, Corinne

AU - Rouaud, Olivier

AU - Manckoundia, Patrick

AU - Quipourt, Valérie

AU - Marilier, Sophie

AU - Franon, Evelyne

AU - Ricolfi, Frédéric

AU - Bories, Lawrence

AU - Pader, Marie Laure

AU - Basset, Marie France

AU - Lapoujade, Bruno

AU - Faure, Valérie

AU - Tong, Michael Li Yung

AU - Malick-Loiseau, Christine

AU - Cazaban-Campistron, Evelyne

AU - Dubois, Dominique

AU - Desclaux, Françoise

AU - Blatge, Colette

AU - Dantoine, Thierry

AU - Laubarie-Mouret, Cécile

AU - Saulnier, Isabelle

AU - Clément, Jean Pierre

AU - Picat, Marie Agnès

AU - Bernard-Bourzeix, Laurence

AU - Willebois, Stéphanie

AU - Désormais, Iléana

AU - Cardinaud, Noëlle

AU - Bonceour Martel, Marie Paule

AU - Monteil, Jacques

AU - Bonnefoy, Marc

AU - Livet, Pierre

AU - Rebaudet, Pascale

AU - Gédéon, Claire

AU - Burdet, Catherine

AU - Terracol, Flavien

AU - Cotton, François

AU - Pesce, Alain

AU - Roth, Stéphanie

AU - Chaillou, Sylvie

AU - Louchart, Sandrine

AU - Sudres, Kristel

AU - Lebrun, Nicolas

AU - Barro-Belaygues, Nadège

AU - Touchon, Jacques

AU - Bennys, Karim

AU - Gabelle, Audrey

AU - Romano, Aurélia

AU - Touati, Lynda

AU - Marelli, Cécilia

AU - Pays, Cécile

AU - Bonafé, Alain

AU - Zanca, Michel

AU - Robert, Philippe

AU - Le Duff, Franck

AU - Gervais, Claire

AU - Gonfrier, Sébastien

AU - Chanalet, Stéphane

AU - Darcourt, Jacques

AU - Gasnier, Yannick

AU - Bordes, Serge

AU - Begorre, Danièle

AU - Carpuat, Christian

AU - Khales, Khaled

AU - Lefebvre, Jean François

AU - El Idrissi, Samira Misbah

AU - Skolil, Pierre

AU - Salles, Jean Pierre

AU - Hugon, Françoise

AU - Lehéricy, Stéphane

AU - Chupin, Marie

AU - Mangin, Jean François

AU - Bouhayia, Ali

PY - 2023/4/1

Y1 - 2023/4/1

N2 - There is growing evidence that cognitive decline can be affected by both nutritional aspects and inflammation. Plasma neurodegenerative biomarkers stand out as minimally invasive useful measures to monitor the potential risk of cognitive decline. This study aimed to investigate the associations between biomarkers of neurodegeneration, nutrition, and inflammation among community-dwelling older adults, and to verify if associations differed according to apolipoprotein E (APOE) ε4 status. This cross-sectional analysis included 475 participants ≥70 years old from the Multidomain Alzheimer Preventive Trial (MAPT), mean age 76.8 years (SD = 4.5), 59.4% women. Biomarkers of neurodegeneration (plasma amyloid-β42/40—Aβ42/40, neurofilament light chain—NfL, progranulin), nutrition (erythrocyte docosahexaenoic acid, eicosapentaenoic acid, omega-3 index; plasma homocysteine—Hcy, 25 hydroxyvitamin D), inflammation (plasma tumor necrosis factor receptor 1—TNFR-1, monocyte chemoattractant protein 1—MCP-1, interleukin 6—IL-6), and cellular stress (plasma growth differentiation factor 15—GDF-15) were assessed. Linear regression analyses were performed to investigate the associations between nutritional and inflammatory biomarkers (independent variables) and neurodegenerative biomarkers (dependent variables), with adjustments for age, sex, education, body mass index, physical activity, allocation to MAPT groups, and APOE ε4 status. After adjusting for confounders, Aβ42/40 was not associated with nutritional or inflammatory markers. NfL was positively associated with GDF-15, TNFR-1, IL-6, and Hcy. Progranulin was positively associated with GDF-15, TNFR-1, and MCP-1. Analyses restricted to APOE ε4 carriers (n = 116; 26.9%) or noncarriers were mostly similar. Our cross-sectional study with community-dwelling older adults corroborates previous evidence that inflammatory pathways are associated to plasma markers of neurodegeneration.

AB - There is growing evidence that cognitive decline can be affected by both nutritional aspects and inflammation. Plasma neurodegenerative biomarkers stand out as minimally invasive useful measures to monitor the potential risk of cognitive decline. This study aimed to investigate the associations between biomarkers of neurodegeneration, nutrition, and inflammation among community-dwelling older adults, and to verify if associations differed according to apolipoprotein E (APOE) ε4 status. This cross-sectional analysis included 475 participants ≥70 years old from the Multidomain Alzheimer Preventive Trial (MAPT), mean age 76.8 years (SD = 4.5), 59.4% women. Biomarkers of neurodegeneration (plasma amyloid-β42/40—Aβ42/40, neurofilament light chain—NfL, progranulin), nutrition (erythrocyte docosahexaenoic acid, eicosapentaenoic acid, omega-3 index; plasma homocysteine—Hcy, 25 hydroxyvitamin D), inflammation (plasma tumor necrosis factor receptor 1—TNFR-1, monocyte chemoattractant protein 1—MCP-1, interleukin 6—IL-6), and cellular stress (plasma growth differentiation factor 15—GDF-15) were assessed. Linear regression analyses were performed to investigate the associations between nutritional and inflammatory biomarkers (independent variables) and neurodegenerative biomarkers (dependent variables), with adjustments for age, sex, education, body mass index, physical activity, allocation to MAPT groups, and APOE ε4 status. After adjusting for confounders, Aβ42/40 was not associated with nutritional or inflammatory markers. NfL was positively associated with GDF-15, TNFR-1, IL-6, and Hcy. Progranulin was positively associated with GDF-15, TNFR-1, and MCP-1. Analyses restricted to APOE ε4 carriers (n = 116; 26.9%) or noncarriers were mostly similar. Our cross-sectional study with community-dwelling older adults corroborates previous evidence that inflammatory pathways are associated to plasma markers of neurodegeneration.

KW - Amyloid-β

KW - Cognitive decline

KW - Inflammation

KW - Neurodegeneration

KW - Nutrition

UR - http://www.scopus.com/inward/record.url?scp=85160448245&partnerID=8YFLogxK

U2 - 10.1093/gerona/glac244

DO - 10.1093/gerona/glac244

M3 - Article

C2 - 36508390

AN - SCOPUS:85160448245

SN - 1079-5006

VL - 78

SP - 569

EP - 578

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

IS - 4

ER -

MAPT/DSA Group, Giudici KV, Barreto PDS, Guyonnet S, Morley JE, Nguyen AD et al. TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study. Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2023 Apr 1;78(4):569-578. doi: 10.1093/gerona/glac244

TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study

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Keywords

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