TY - JOUR
T1 - Tissue Stress and Tumor Promotion
T2 - Possible Relevance to Epidermolysis Bullosa
AU - Goldberg, Gregory I.
AU - Eisen, Arthur Z.
AU - Bauer, Eugene A.
PY - 1988/5
Y1 - 1988/5
N2 - Cutaneous carcinomas often arise in patients with severe epidermolysis bullosa (or other cutaneous ulcers) at multiple primary sites. Chronic tissue stress thus appears to promote carcinogenesis in preexisting somatic mutants in a stem cell population. Altered contractile properties of fibroblasts cultured from skin with epidermolysis bullosa may result from an altered interaction of these cells with their surrounding, chronically stressed, connective tissue matrix.
AB - Cutaneous carcinomas often arise in patients with severe epidermolysis bullosa (or other cutaneous ulcers) at multiple primary sites. Chronic tissue stress thus appears to promote carcinogenesis in preexisting somatic mutants in a stem cell population. Altered contractile properties of fibroblasts cultured from skin with epidermolysis bullosa may result from an altered interaction of these cells with their surrounding, chronically stressed, connective tissue matrix.
UR - http://www.scopus.com/inward/record.url?scp=0023895955&partnerID=8YFLogxK
U2 - 10.1001/archderm.1988.01670050081027
DO - 10.1001/archderm.1988.01670050081027
M3 - Article
C2 - 3284472
AN - SCOPUS:0023895955
SN - 0003-987X
VL - 124
SP - 737
EP - 741
JO - Archives of Dermatology
JF - Archives of Dermatology
IS - 5
ER -