Tissue Stress and Tumor Promotion: Possible Relevance to Epidermolysis Bullosa

Gregory I. Goldberg, Arthur Z. Eisen, Eugene A. Bauer

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Cutaneous carcinomas often arise in patients with severe epidermolysis bullosa (or other cutaneous ulcers) at multiple primary sites. Chronic tissue stress thus appears to promote carcinogenesis in preexisting somatic mutants in a stem cell population. Altered contractile properties of fibroblasts cultured from skin with epidermolysis bullosa may result from an altered interaction of these cells with their surrounding, chronically stressed, connective tissue matrix.

Original languageEnglish
Pages (from-to)737-741
Number of pages5
JournalArchives of dermatology
Volume124
Issue number5
DOIs
StatePublished - May 1988

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