Tissue-resident natural killer cells and their potential diversity

Dorothy K. Sojka; Zhigang Tian; Wayne M. Yokoyama

doi:10.1016/j.smim.2014.01.010

Tissue-resident natural killer cells and their potential diversity

Dorothy K. Sojka, Zhigang Tian, Wayne M. Yokoyama

Research output: Contribution to journal › Review article › peer-review

94 Scopus citations

Abstract

Conventional NK cells are well characterized in the mouse spleen and circulate in the blood. Less well described are NK cells found in organs such as the liver, thymus, and uterus. Recently we identified a tissue-resident NK (trNK) cell population in the liver, suggesting a potential diversity of trNK cells in other organs. In this review we compare and contrast the similarities and differences among the subpopulations of NK and innate lymphoid cells to the trNK cells in the liver.

Original language	English
Pages (from-to)	127-131
Number of pages	5
Journal	Seminars in immunology
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/j.smim.2014.01.010
State	Published - Apr 2014

Keywords

Innate lymphoid-like cells
Liver
NK cells
Tissue-resident

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10.1016/j.smim.2014.01.010

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title = "Tissue-resident natural killer cells and their potential diversity",

abstract = "Conventional NK cells are well characterized in the mouse spleen and circulate in the blood. Less well described are NK cells found in organs such as the liver, thymus, and uterus. Recently we identified a tissue-resident NK (trNK) cell population in the liver, suggesting a potential diversity of trNK cells in other organs. In this review we compare and contrast the similarities and differences among the subpopulations of NK and innate lymphoid cells to the trNK cells in the liver.",

keywords = "Innate lymphoid-like cells, Liver, NK cells, Tissue-resident",

author = "Sojka, {Dorothy K.} and Zhigang Tian and Yokoyama, {Wayne M.}",

note = "Funding Information: We thank the Yokoyama lab for great discussions. Studies in the Yokoyama laboratory are supported by RO1-AI106561 from the National Institutes of Health . W.M.Y. is an Investigator of the Howard Hughes Medical Institute. D.K.S. is supported by T32 CA009547 from the National Institutes of Health . ",

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AU - Sojka, Dorothy K.

AU - Tian, Zhigang

AU - Yokoyama, Wayne M.

N1 - Funding Information: We thank the Yokoyama lab for great discussions. Studies in the Yokoyama laboratory are supported by RO1-AI106561 from the National Institutes of Health . W.M.Y. is an Investigator of the Howard Hughes Medical Institute. D.K.S. is supported by T32 CA009547 from the National Institutes of Health .

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N2 - Conventional NK cells are well characterized in the mouse spleen and circulate in the blood. Less well described are NK cells found in organs such as the liver, thymus, and uterus. Recently we identified a tissue-resident NK (trNK) cell population in the liver, suggesting a potential diversity of trNK cells in other organs. In this review we compare and contrast the similarities and differences among the subpopulations of NK and innate lymphoid cells to the trNK cells in the liver.

AB - Conventional NK cells are well characterized in the mouse spleen and circulate in the blood. Less well described are NK cells found in organs such as the liver, thymus, and uterus. Recently we identified a tissue-resident NK (trNK) cell population in the liver, suggesting a potential diversity of trNK cells in other organs. In this review we compare and contrast the similarities and differences among the subpopulations of NK and innate lymphoid cells to the trNK cells in the liver.

KW - Innate lymphoid-like cells

KW - Liver

KW - NK cells

KW - Tissue-resident

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JO - Seminars in immunology

JF - Seminars in immunology

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Tissue-resident natural killer cells and their potential diversity

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Keywords

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