TY - JOUR
T1 - Tissue-resident natural killer cells
AU - Yokoyama, Wayne M.
AU - Sojka, Dorothy K.
AU - Peng, Hui
AU - Tian, Zhigang
PY - 2013
Y1 - 2013
N2 - Natural killer (NK) cells kill infected and tumor cells and produce cytokines that modulate other immune cells. However, most of our current knowledge is derived from investigations of mouse splenic and human peripheral blood NK cells, "conventional" NK cells. Herein we discuss recent studies indicating that the liver contains two subpopulations of NK cells, one of which is liver-resident and bears distinct markers from another liver subpopulation that resembles conventional NK cells. Thus, the liver and potentially other organs contain tissue-resident NK cells that may differ from conventional NK cells in terms of origin, development, and/or function.
AB - Natural killer (NK) cells kill infected and tumor cells and produce cytokines that modulate other immune cells. However, most of our current knowledge is derived from investigations of mouse splenic and human peripheral blood NK cells, "conventional" NK cells. Herein we discuss recent studies indicating that the liver contains two subpopulations of NK cells, one of which is liver-resident and bears distinct markers from another liver subpopulation that resembles conventional NK cells. Thus, the liver and potentially other organs contain tissue-resident NK cells that may differ from conventional NK cells in terms of origin, development, and/or function.
UR - http://www.scopus.com/inward/record.url?scp=84904875696&partnerID=8YFLogxK
U2 - 10.1101/sqb.2013.78.020354
DO - 10.1101/sqb.2013.78.020354
M3 - Article
C2 - 24584057
AN - SCOPUS:84904875696
SN - 0091-7451
VL - 78
SP - 149
EP - 156
JO - Cold Spring Harbor symposia on quantitative biology
JF - Cold Spring Harbor symposia on quantitative biology
IS - 1
ER -