Tissue factor pathway inhibitor and the revised theory of coagulation

G. J. Broze

Research output: Contribution to journalReview articlepeer-review

280 Scopus citations

Abstract

Tissue factor pathway inhibitor (TFPI) is a multivalent, Kunitz-type plasma proteinase inhibitor that regulates tissue factor-induced coagulation. TFPI directly inhibits activated factor X and, in a factor Xa-dependent fashion, produces feedback inhibition of the factor VIIa/ssue factor catalytic complex. The properties of this rediscovered inhibitor appear, at least in part, to explain the clinical requirement for both the extrinsic and intrinsic pathways of the cascade and waterfall theories of blood clotting and have led to a reformulation of the coagulation mechanism. In the revised hypothesis, factor VIIa/tissue factor is responsible for the initiation of coagulation, but owing to TFPI-mediated inhibition, sustained hemostasis requires the persistent and amplified procoagulant action of intrinsic factors VIII, IX, and XI.

Original languageEnglish
Pages (from-to)103-112
Number of pages10
JournalAnnual review of medicine
Volume46
DOIs
StatePublished - 1995

Keywords

  • Cascade
  • Kunitz
  • Proteinase

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