Tissue factor pathway inhibitor and the current concept of blood coagulation

G. J. Broze

Research output: Contribution to journalArticle

163 Scopus citations

Abstract

Tissue factor pathway inhibitor (TFPI) is a multivalent, Kunitz-type plasma proteinase inhibitor that regulates tissue factor-induced coagulation. TFPI directly inhibits activated factor X and, in a factor Xa-dependent manner, produces feedback inhibition of the factor VIIa/tissue factor catalytic complex. The properties of this inhibitor help explain the clinical need for 'extrinsic' and 'intrinsic' coagulation pathways and have led to a reformulation of the coagulation cascade. In the revised hypothesis, factor VIIa/tissue factor is responsible for the initiation of coagulation but, owing to TFPI-mediated feedback inhibition, amplification of the procoagulant response though the actions of factor VIII, IX and XI is required for sustained haemostasis.

Original languageEnglish
Pages (from-to)S7-S13
JournalBlood Coagulation and Fibrinolysis
Volume6
Issue numberSUPPL. 1
StatePublished - Jan 1 1995

Keywords

  • Cascade
  • Haemophilia
  • Kunitz
  • Review
  • Tissue factor
  • Tissue factor pathway inhibitor

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