Tissue Engineering and Conduit Substitution

Scott C. Johnson, Zachary L. Smith, Bryan S. Sack, Gary D. Steinberg

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Radical cystectomy (RC) with urinary diversion is associated with significant morbidity, much of which arises from the interposition of bowel segments in the urinary system. A tissue-engineered alternative for urinary diversion could dramatically reduce the perioperative and long-term morbidity associated with RC. Attempts at developing a tissue-engineered incontinent urinary conduit (TEUC) have involved mechanical scaffolds and promoting tissue growth within them. Despite some preclinical success, significant obstacles remain before a TEUC is ready for clinical use. A further understanding of tissue and materials engineering may help overcome these obstacles or help to develop a new approach to tissue engineering entirely.

Original languageEnglish
Pages (from-to)133-141
Number of pages9
JournalUrologic Clinics of North America
Issue number1
StatePublished - Feb 2018


  • Radical cystectomy
  • Regenerative medicine
  • Scaffolds
  • Tissue engineering
  • Urinary diversion


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