TY - JOUR
T1 - Timolol Plus Maximum-Tolerated Antiglaucoma Therapy
AU - Zimmerman, Thom J.
AU - Gillespie, James E.
AU - Kass, Michael A.
AU - Yablonski, Michael E.
AU - Becker, Bernard
PY - 1979/2
Y1 - 1979/2
N2 - Eighteen patients with glaucoma with a mean intraocular pressure (IOP) ± SD of 28.7 ± 5.5 mm Hg who were receiving maximum-tolerated antiglaucoma therapy were given 0.5% timolol maleate or a placebo twice daily to one eye in a double-masked cross-over fashion in addition to their usual antiglaucoma drugs. After one week of timolol therapy, the mean IOP was significantly lower (23.1 ± 4.1 mm Hg) than after one week of placebo administration (26.4 ± 7.8 mm Hg; P <.025, paired t test). Five patients had decreases in IOP >4 mm Hg, while six patients reached IOPs < 21 mm Hg while receiving timolol therapy. No adverse reactions to timolol were noted. Timolol had an additional IOP-lowering effect in some patients receiving maximum-tolerated medical therapy.
AB - Eighteen patients with glaucoma with a mean intraocular pressure (IOP) ± SD of 28.7 ± 5.5 mm Hg who were receiving maximum-tolerated antiglaucoma therapy were given 0.5% timolol maleate or a placebo twice daily to one eye in a double-masked cross-over fashion in addition to their usual antiglaucoma drugs. After one week of timolol therapy, the mean IOP was significantly lower (23.1 ± 4.1 mm Hg) than after one week of placebo administration (26.4 ± 7.8 mm Hg; P <.025, paired t test). Five patients had decreases in IOP >4 mm Hg, while six patients reached IOPs < 21 mm Hg while receiving timolol therapy. No adverse reactions to timolol were noted. Timolol had an additional IOP-lowering effect in some patients receiving maximum-tolerated medical therapy.
UR - http://www.scopus.com/inward/record.url?scp=0018350664&partnerID=8YFLogxK
U2 - 10.1001/archopht.1979.01020010130005
DO - 10.1001/archopht.1979.01020010130005
M3 - Article
C2 - 399180
AN - SCOPUS:0018350664
SN - 0003-9950
VL - 97
SP - 278
EP - 279
JO - Archives of Ophthalmology
JF - Archives of Ophthalmology
IS - 2
ER -