Timolol and Epinephrine: A Clinical Study of Ocular Interactions

Ivan Goldberg, Frank S. Ashburn, Paul F. Palmberg, Michael A. Kass, Bernard Becker

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


In a crossover design study, we assessed effects on intraocular pressure, pupillary diameter, pulse rate, and blood pressure over six hours of one drop of 0.5% timolol maleate and 2% epinephrine hydrochloride in one eye. Both eyes of each patient had been pretreated for one week with twice-daily applications of epinephrine or timolol, respectively. In random sequence, 20 patients (40 eyes) participated in both phases of the study. Pretreatment with timolol significantly reduced the ocular hypotensive effect of epinephrine (from 15.3% to 4.6%); epinephrine pretreatment did not affect the pressure reduction of timolol. Pretreatment with timolol enhanced the mydriatic effect of epinephrine (from 35.8% to 71.9% pupillary dilation); pretreatment with epinephrine resulted in an apparent mydriatic effect for timolol.

Original languageEnglish
Pages (from-to)484-486
Number of pages3
JournalArchives of Ophthalmology
Issue number3
StatePublished - Mar 1980


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