Timing and magnitude of type i interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection

Yaming Wang, Melissa Swiecki, Marina Cella, Gottfried Alber, Robert D. Schreiber, Susan Gilfillan, Marco Colonna

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

Type I interferon (IFN-I) promotes antiviral CD8 +T cell responses, but the contribution of different IFN-I sources and signaling pathways are ill defined. While plasmacytoid dendritic cells (pDCs) produce IFN-I upon TLR stimulation, IFN-I is induced in most cells by helicases like MDA5. Using acute and chronic lymphocytic choriomeningitis virus (LCMV) infection models, we determined that pDCs transiently produce IFN-I that minimally impacts CD8 +T cell responses and viral persistence. Rather, MDA5 is the key sensor that induces IFN-I required for CD8 +T cell responses. In the absence of MDA5, CD8 +T cell responses to acute infection rely on CD4 +T cell help, and loss of both CD4 +T cells and MDA5 results in CD8 +T cell exhaustion and persistent infection. Chronic LCMV infection rapidly attenuates IFN-I responses, but early administration of exogenous IFN-I rescues CD8 +T cells, promoting viral clearance. Thus, effective antiviral CD8 +T cell responses depend on the timing and magnitude of IFN-I production.

Original languageEnglish
Pages (from-to)631-642
Number of pages12
JournalCell Host and Microbe
Volume11
Issue number6
DOIs
StatePublished - Jun 14 2012

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