TIMely connections: APOE4, aging, and Alzheimer's

Qingyun Li

doi:10.1016/j.immuni.2023.12.015

TIMely connections: APOE4, aging, and Alzheimer's

Qingyun Li

Research output: Contribution to journal › Comment/debate

3 Scopus citations

Abstract

How do APOE4 and aging, two of the strongest risk factors for late-onset Alzheimer's disease (AD), promote disease progression? In this issue of Immunity, Millet et al. examine microglia in AD mice bearing different APOE alleles at distinct ages and identify a conserved exhausted-like microglial state enriched in very elderly and APOE4 AD brains.

Original language	English
Pages (from-to)	8-10
Number of pages	3
Journal	Immunity
Volume	57
Issue number	1
DOIs	https://doi.org/10.1016/j.immuni.2023.12.015
State	Published - Jan 9 2024

Access to Document

10.1016/j.immuni.2023.12.015

Cite this

@article{d9aaf82b345c4b6ba13107bdbdf81b4e,

title = "TIMely connections: APOE4, aging, and Alzheimer's",

abstract = "How do APOE4 and aging, two of the strongest risk factors for late-onset Alzheimer's disease (AD), promote disease progression? In this issue of Immunity, Millet et al. examine microglia in AD mice bearing different APOE alleles at distinct ages and identify a conserved exhausted-like microglial state enriched in very elderly and APOE4 AD brains.",

author = "Qingyun Li",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2024",

month = jan,

day = "9",

doi = "10.1016/j.immuni.2023.12.015",

language = "English",

volume = "57",

pages = "8--10",

journal = "Immunity",

issn = "1074-7613",

number = "1",

}

TY - JOUR

T1 - TIMely connections

T2 - APOE4, aging, and Alzheimer's

AU - Li, Qingyun

PY - 2024/1/9

Y1 - 2024/1/9

N2 - How do APOE4 and aging, two of the strongest risk factors for late-onset Alzheimer's disease (AD), promote disease progression? In this issue of Immunity, Millet et al. examine microglia in AD mice bearing different APOE alleles at distinct ages and identify a conserved exhausted-like microglial state enriched in very elderly and APOE4 AD brains.

AB - How do APOE4 and aging, two of the strongest risk factors for late-onset Alzheimer's disease (AD), promote disease progression? In this issue of Immunity, Millet et al. examine microglia in AD mice bearing different APOE alleles at distinct ages and identify a conserved exhausted-like microglial state enriched in very elderly and APOE4 AD brains.

UR - https://www.scopus.com/pages/publications/85181844716

U2 - 10.1016/j.immuni.2023.12.015

DO - 10.1016/j.immuni.2023.12.015

M3 - Comment/debate

C2 - 38198855

AN - SCOPUS:85181844716

SN - 1074-7613

VL - 57

SP - 8

EP - 10

JO - Immunity

JF - Immunity

IS - 1

ER -

TIMely connections: APOE4, aging, and Alzheimer's

Abstract

Access to Document

Other files and links

Fingerprint

Cite this