TIMely connections: APOE4, aging, and Alzheimer's

Qingyun Li

doi:10.1016/j.immuni.2023.12.015

TIMely connections: APOE4, aging, and Alzheimer's

Research output: Contribution to journal › Comment/debate

Abstract

How do APOE4 and aging, two of the strongest risk factors for late-onset Alzheimer's disease (AD), promote disease progression? In this issue of Immunity, Millet et al. examine microglia in AD mice bearing different APOE alleles at distinct ages and identify a conserved exhausted-like microglial state enriched in very elderly and APOE4 AD brains.

Original language	English
Pages (from-to)	8-10
Number of pages	3
Journal	Immunity
Volume	57
Issue number	1
DOIs	https://doi.org/10.1016/j.immuni.2023.12.015
State	Published - Jan 9 2024

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title = "TIMely connections: APOE4, aging, and Alzheimer's",

abstract = "How do APOE4 and aging, two of the strongest risk factors for late-onset Alzheimer's disease (AD), promote disease progression? In this issue of Immunity, Millet et al. examine microglia in AD mice bearing different APOE alleles at distinct ages and identify a conserved exhausted-like microglial state enriched in very elderly and APOE4 AD brains.",

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TIMely connections: APOE4, aging, and Alzheimer's

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