Time resolved speckle contrast optical spectroscopy at quasi-null source-detector separation for non-invasive measurement of microvascular blood flow

Marco Pagliazzi, Lorenzo Colombo, Ernesto E. Vidal-Rosas, Tanja Dragojevic, Veronika Parfentyeva, Joseph P. Culver, Sanathana Konugolu Venkata Sekar, Laura Di Sieno, Davide Contini, Alessandro Torricelli, Antonio Pifferi, Alberto Dalla Mora, Turgut Durduran

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Time (or path length) resolved speckle contrast optical spectroscopy (TD-SCOS) at quasi-null (2.85 mm) source-detector separation was developed and demonstrated. The method was illustrated by in vivo studies on the forearm muscle of an adult subject. The results have shown that selecting longer photon path lengths results in higher hyperemic blood flow change and a faster return to baseline by a factor of two after arterial cuff occlusion when compared to SCOS without time resolution. This indicates higher sensitivity to the deeper muscle tissue. In the long run, this approach may allow the use of simpler and cheaper detector arrays compared to time resolved diffuse correlation spectroscopy that are based on readily available technologies. Hence, TD-SCOS may increase the performance and decrease cost of devices for continuous non-invasive, deep tissue blood flow monitoring.

Original languageEnglish
Pages (from-to)1499-1511
Number of pages13
JournalBiomedical Optics Express
Volume12
Issue number3
DOIs
StatePublished - Mar 1 2021

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