Time domain measurements of heart rate variability

R. E. Kleiger, P. K. Stein, M. S. Bosner, J. N. Rottman

Research output: Contribution to journalReview articlepeer-review

245 Scopus citations


Assessment of HRV through time domain variables is a simple and practical method of assessing autonomic function. In this capacity its utility has been demonstrated in normal subjects and in diverse cardiac and noncardiac pathologic states. It can be used to assess the effects of drugs and other interventions, including exercise and psychological and physical stress on cardiac autonomic tone. Importantly, decreased HRV is almost uniformly associated with adverse outcome. The prognostic information appears to incorporate both alterations in autonomic tone and longer term components and is best assessed using ambulatory ECG recordings. Defining the clinical applicability and physiologic mechanisms of changes in HRV remain active areas of research.

Original languageEnglish
Pages (from-to)487-498
Number of pages12
JournalCardiology clinics
Issue number3
StatePublished - 1992


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