Tight Disease Control in Early RA

Deepali Sen, Richard Brasington

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


The past decade has brought increasing evidence to support aggressive therapeutic intervention in early rheumatoid arthritis (RA). Treat-to-target strategies that focus on frequent monitoring and treatment adjustments to achieve states of low disease activity or clinical remission have shown superior long-term results. Both oral disease-modifying antirheumatic drugs and biologic agents are effective in treating early RA. It remains unclear if initial combination therapy or biologic use is more effective in early active disease as compared with the traditional approach. The authors review various studies on the treatment of early RA with a focus on studies with a treat-to-target approach.

Original languageEnglish
Pages (from-to)327-343
Number of pages17
JournalRheumatic Disease Clinics of North America
Issue number2
StatePublished - May 2012


  • Early RA
  • Rheumatoid arthritis
  • Tight control
  • Treatment


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