Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

Brian D. Evavold, Joanne Sloan-Lancaster, Paul M. Allen

Research output: Contribution to journalReview articlepeer-review

394 Scopus citations

Abstract

Recent observations of T-cell responses following T-cell receptor (TCR) interaction with altered peptide ligands have highlighted the complexity of this signalling system. The indications are that the TCR responds to minor changes in ligand with gradations of T-cell activation and effector functions. Brian Evavold, Joanne Sloan-Lancaster and Paul Allen review these studies and present a model in which partial T-cell activation and TCR antagonism are related events in a continuum of signalling through the TCR.

Original languageEnglish
Pages (from-to)602-609
Number of pages8
JournalImmunology today
Volume14
Issue number12
DOIs
StatePublished - Dec 1993

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