Thyroid carcinoma uptake of 18 F-Fluorodeoxyglucose in patients with elevated serum thyroglobulin and negative 131I scintigraphy

Kimberly M. Creach; Brian Nussenbaum; Barry A. Siegel; Perry W. Grigsby

doi:10.1016/j.amjoto.2012.08.006

Thyroid carcinoma uptake of ¹⁸ F-Fluorodeoxyglucose in patients with elevated serum thyroglobulin and negative ¹³¹I scintigraphy

Kimberly M. Creach, Brian Nussenbaum, Barry A. Siegel, Perry W. Grigsby

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Purpose: To determine if FDG-PET results can predict for outcome in thyroid cancer patients with elevated Tg and negative I-131 imaging. Materials and methods: We conducted a retrospective review of 76 patients who had elevated serum Tg and negative ¹³¹I scintigraphy and who underwent FDG-PET. After FDG-PET, patients underwent neck dissection or radiation. Results: The 51 patients with positive FDG-PET had a 5-year survival of 63% compared to 100% (p < 0.049) for the 25 patients with negative PET. Patients with FDG-avid disease isolated to the lymph nodes had 5-year CSS of 91% compared to 32% (p = 0.0033) for those with disease outside the regional lymph nodes. Twenty-nine patients with disease isolated to the regional lymph nodes underwent salvage neck dissection and 22 remain NED after 28 months. Conclusions: Negative FDG-PET with elevated Tg predicts an excellent outcome. FDG-avid disease isolated to the regional lymph nodes had a low likelihood of death due to thyroid cancer.

Original language	English
Pages (from-to)	51-56
Number of pages	6
Journal	American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.amjoto.2012.08.006
State	Published - Jan 2013

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10.1016/j.amjoto.2012.08.006

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title = "Thyroid carcinoma uptake of 18 F-Fluorodeoxyglucose in patients with elevated serum thyroglobulin and negative 131I scintigraphy",

abstract = "Purpose: To determine if FDG-PET results can predict for outcome in thyroid cancer patients with elevated Tg and negative I-131 imaging. Materials and methods: We conducted a retrospective review of 76 patients who had elevated serum Tg and negative 131I scintigraphy and who underwent FDG-PET. After FDG-PET, patients underwent neck dissection or radiation. Results: The 51 patients with positive FDG-PET had a 5-year survival of 63% compared to 100% (p < 0.049) for the 25 patients with negative PET. Patients with FDG-avid disease isolated to the lymph nodes had 5-year CSS of 91% compared to 32% (p = 0.0033) for those with disease outside the regional lymph nodes. Twenty-nine patients with disease isolated to the regional lymph nodes underwent salvage neck dissection and 22 remain NED after 28 months. Conclusions: Negative FDG-PET with elevated Tg predicts an excellent outcome. FDG-avid disease isolated to the regional lymph nodes had a low likelihood of death due to thyroid cancer.",

author = "Creach, {Kimberly M.} and Brian Nussenbaum and Siegel, {Barry A.} and Grigsby, {Perry W.}",

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Thyroid carcinoma uptake of ¹⁸ F-Fluorodeoxyglucose in patients with elevated serum thyroglobulin and negative ¹³¹I scintigraphy. / Creach, Kimberly M.; Nussenbaum, Brian; Siegel, Barry A. et al.
In: American Journal of Otolaryngology - Head and Neck Medicine and Surgery, Vol. 34, No. 1, 01.2013, p. 51-56.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Thyroid carcinoma uptake of 18 F-Fluorodeoxyglucose in patients with elevated serum thyroglobulin and negative 131I scintigraphy

AU - Creach, Kimberly M.

AU - Nussenbaum, Brian

AU - Siegel, Barry A.

AU - Grigsby, Perry W.

PY - 2013/1

Y1 - 2013/1

N2 - Purpose: To determine if FDG-PET results can predict for outcome in thyroid cancer patients with elevated Tg and negative I-131 imaging. Materials and methods: We conducted a retrospective review of 76 patients who had elevated serum Tg and negative 131I scintigraphy and who underwent FDG-PET. After FDG-PET, patients underwent neck dissection or radiation. Results: The 51 patients with positive FDG-PET had a 5-year survival of 63% compared to 100% (p < 0.049) for the 25 patients with negative PET. Patients with FDG-avid disease isolated to the lymph nodes had 5-year CSS of 91% compared to 32% (p = 0.0033) for those with disease outside the regional lymph nodes. Twenty-nine patients with disease isolated to the regional lymph nodes underwent salvage neck dissection and 22 remain NED after 28 months. Conclusions: Negative FDG-PET with elevated Tg predicts an excellent outcome. FDG-avid disease isolated to the regional lymph nodes had a low likelihood of death due to thyroid cancer.

AB - Purpose: To determine if FDG-PET results can predict for outcome in thyroid cancer patients with elevated Tg and negative I-131 imaging. Materials and methods: We conducted a retrospective review of 76 patients who had elevated serum Tg and negative 131I scintigraphy and who underwent FDG-PET. After FDG-PET, patients underwent neck dissection or radiation. Results: The 51 patients with positive FDG-PET had a 5-year survival of 63% compared to 100% (p < 0.049) for the 25 patients with negative PET. Patients with FDG-avid disease isolated to the lymph nodes had 5-year CSS of 91% compared to 32% (p = 0.0033) for those with disease outside the regional lymph nodes. Twenty-nine patients with disease isolated to the regional lymph nodes underwent salvage neck dissection and 22 remain NED after 28 months. Conclusions: Negative FDG-PET with elevated Tg predicts an excellent outcome. FDG-avid disease isolated to the regional lymph nodes had a low likelihood of death due to thyroid cancer.

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JO - American Journal of Otolaryngology - Head and Neck Medicine and Surgery

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Thyroid carcinoma uptake of ¹⁸ F-Fluorodeoxyglucose in patients with elevated serum thyroglobulin and negative ¹³¹I scintigraphy

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