Abstract
We have described a procedure for isolating thymic macrophages and have evaluated their activity in stimulating thymocyte maturation in vitro. The culturing of gradient-purified immature thymocytes on thymic macrophages leads to an increased expression of h-2 antigens and decreased lytic sensitivity with anti-TL and C. The macrophage-stimulated thymocyte also acquires the ability to respond in the MLR. We propose that the macrophage may regulate one stage of thymic differentiation in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 1861-1864 |
| Number of pages | 4 |
| Journal | Journal of Immunology |
| Volume | 121 |
| Issue number | 5 |
| State | Published - Dec 1 1978 |