Thymic macrophages modulate one stage of T cell differentiation in vitro

D. I. Beller, E. R. Unanue

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

We have described a procedure for isolating thymic macrophages and have evaluated their activity in stimulating thymocyte maturation in vitro. The culturing of gradient-purified immature thymocytes on thymic macrophages leads to an increased expression of h-2 antigens and decreased lytic sensitivity with anti-TL and C. The macrophage-stimulated thymocyte also acquires the ability to respond in the MLR. We propose that the macrophage may regulate one stage of thymic differentiation in vivo.

Original languageEnglish
Pages (from-to)1861-1864
Number of pages4
JournalJournal of Immunology
Volume121
Issue number5
StatePublished - Dec 1 1978

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