TY - JOUR
T1 - Thrombotic thrombocytopenic purpura in a patient treated with imatinib mesylate
T2 - True association or mere coincidence?
AU - Al Aly, Ziyad
AU - Philoctête Ashley, Jennifer M.
AU - Gellens, Mary E.
AU - González, Esther A.
PY - 2005/4
Y1 - 2005/4
N2 - Thrombotic thrombocytopenic purpura (TTP), characterized by thrombocytopenia and microangiopathic hemolytic anemia, is a relatively rare disorder. The majority of cases have no defined causes. TTP has been reported in association with many drugs, but not with imatinib mesylate. We report a 22-year-old African-American woman who developed idiopathic hypereosinophilic syndrome. She was treated with imatinib mesylate and subsequently developed microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. TTP was diagnosed. A kidney biopsy was performed and was diagnostic of thrombotic microangiopathy. The patient was treated with plasma exchange and hemodialysis. Her eosinophilia resolved, but she remained dialysis dependent. To our knowledge, this is the first case report of the possible association between imatinib mesylate and TTP.
AB - Thrombotic thrombocytopenic purpura (TTP), characterized by thrombocytopenia and microangiopathic hemolytic anemia, is a relatively rare disorder. The majority of cases have no defined causes. TTP has been reported in association with many drugs, but not with imatinib mesylate. We report a 22-year-old African-American woman who developed idiopathic hypereosinophilic syndrome. She was treated with imatinib mesylate and subsequently developed microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. TTP was diagnosed. A kidney biopsy was performed and was diagnostic of thrombotic microangiopathy. The patient was treated with plasma exchange and hemodialysis. Her eosinophilia resolved, but she remained dialysis dependent. To our knowledge, this is the first case report of the possible association between imatinib mesylate and TTP.
KW - Thrombotic thrombocytopenic purpura (TTP)
KW - acute renal failure
KW - hypereosinophilic syndrome (HES)
KW - imatinib mesylate (Gleevec; Novartis Pharmaceuticals, East Hanover, NJ)
KW - thrombotic microangiopathy
UR - http://www.scopus.com/inward/record.url?scp=16244385891&partnerID=8YFLogxK
U2 - 10.1053/j.ajkd.2004.12.017
DO - 10.1053/j.ajkd.2004.12.017
M3 - Article
C2 - 15806480
AN - SCOPUS:16244385891
VL - 45
SP - 762
EP - 768
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
SN - 0272-6386
IS - 4
ER -