TY - JOUR
T1 - Thrombotic Microangiopathy in Pregnancy
T2 - Current Understanding and Management Strategies
AU - Urra, Manuel
AU - Lyons, Shannon
AU - Teodosiu, Corina Gabriela
AU - Burwick, Richard
AU - Java, Anuja
N1 - Publisher Copyright:
© 2024 International Society of Nephrology
PY - 2024/8
Y1 - 2024/8
N2 - Thrombotic microangiopathy (TMA) represents a heterogeneous group of disorders characterized by microvascular thrombosis and end-organ damage. Pregnancy-associated thrombotic microangiopathy (p-TMA) has emerged as a distinct clinical entity with unique diagnostic challenges. Identifying the specific form of p-TMA is critical for appropriate and timely management. This review offers a comprehensive overview of the various forms of thrombotic microangiopathies associated with pregnancy, highlighting our current understanding of their pathophysiology and the evolving landscape of diagnosis and treatment for each.
AB - Thrombotic microangiopathy (TMA) represents a heterogeneous group of disorders characterized by microvascular thrombosis and end-organ damage. Pregnancy-associated thrombotic microangiopathy (p-TMA) has emerged as a distinct clinical entity with unique diagnostic challenges. Identifying the specific form of p-TMA is critical for appropriate and timely management. This review offers a comprehensive overview of the various forms of thrombotic microangiopathies associated with pregnancy, highlighting our current understanding of their pathophysiology and the evolving landscape of diagnosis and treatment for each.
KW - complement
KW - microangiopathic hemolytic anemia
KW - pregnancy
KW - thrombocytopenia
KW - thrombotic microangiopathy
UR - http://www.scopus.com/inward/record.url?scp=85196093203&partnerID=8YFLogxK
U2 - 10.1016/j.ekir.2024.05.016
DO - 10.1016/j.ekir.2024.05.016
M3 - Review article
AN - SCOPUS:85196093203
SN - 2468-0249
VL - 9
SP - 2353
EP - 2371
JO - Kidney International Reports
JF - Kidney International Reports
IS - 8
ER -