Thrombocytopenia in an established solitary pancreas graft recipient

Enrico Benedetti, John R. Kirby, Massimo Asolati, Michael L. Mihalov, Luna Ghosh, Raymond Pollak

Research output: Contribution to journalArticlepeer-review

Abstract

Isolated, life-threatening thrombocytopenia from a previously well tolerated pancreas allograft has not been reported in the literature. Herein we report such a case where a 31-year-old, Caucasian, Type I diabetic male developed severe thrombocytopenia 6 months following isolated pancreas transplantation and 2 wk after enteric conversion of the graft. Despite extensive diagnostic work-up, the cause remained unclear and his thrombocytopenia did not remit with standard treatment, but did resolve upon explantation. Pathologic examination of the pancreatic graft showed evidence of chronic rejection along with CMV pancreatitis. We conclude that unremitting isolated thrombocytopenia in solitary pancreas grafts may reflect a localized DIC phenomenon that requires graft explantation.

Original languageEnglish
Pages (from-to)438-441
Number of pages4
JournalClinical Transplantation
Volume11
Issue number5 I
StatePublished - Oct 1 1997
Externally publishedYes

Keywords

  • Immunosuppression
  • Pancreas transplant
  • Thrombocytopenia

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