TY - JOUR
T1 - Thrombocytopenia associated with octreotide
AU - Demirkan, Kutay
AU - Fleckenstein, Jaquelyn F.
AU - Self, Timothy H.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - A 42-year-old woman with a history of hepatitis C-induced cirrhosis, gastrointestinal bleeding, and alcohol abuse presented to the hospital with hematemesis and melena. Based on our previous experience, octreotide (Sandostatin) therapy was started at 50 mg/hr and continued for 5 days. Platelet count on admission (122 x 109/L) dropped immediately after octreotide therapy was started; upon discontinuation, platelet count began trending up from 72 x 109/L. However, octreotide was not suspected at this point as the cause of thrombocytopenia. In a subsequent admission, octreotide was again administered with a resultant prompt decrease in platelet count. To our knowledge, this is only the second case report of octreotide-induced thrombocytopenia, and the first case of this adverse effect demonstrated by inadvertent rechallenge.
AB - A 42-year-old woman with a history of hepatitis C-induced cirrhosis, gastrointestinal bleeding, and alcohol abuse presented to the hospital with hematemesis and melena. Based on our previous experience, octreotide (Sandostatin) therapy was started at 50 mg/hr and continued for 5 days. Platelet count on admission (122 x 109/L) dropped immediately after octreotide therapy was started; upon discontinuation, platelet count began trending up from 72 x 109/L. However, octreotide was not suspected at this point as the cause of thrombocytopenia. In a subsequent admission, octreotide was again administered with a resultant prompt decrease in platelet count. To our knowledge, this is only the second case report of octreotide-induced thrombocytopenia, and the first case of this adverse effect demonstrated by inadvertent rechallenge.
KW - Octreotide
KW - Thrombocytopenia
UR - http://www.scopus.com/inward/record.url?scp=0033789486&partnerID=8YFLogxK
U2 - 10.1016/S0002-9629(15)40844-4
DO - 10.1016/S0002-9629(15)40844-4
M3 - Article
C2 - 11061359
AN - SCOPUS:0033789486
VL - 320
SP - 296
EP - 297
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
SN - 0002-9629
IS - 4
ER -