Three-Dimensional Printing Antimicrobial and Radiopaque Constructs

Christen J. Boyer, David H. Ballard, Jeffery A. Weisman, Spencer Hurst, David J. McGee, David K. Mills, Jennifer E. Woerner, Uday Jammalamadaka, Karthik Tappa, Jonathan Steven Alexander

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Three-dimensional (3D) printing holds tremendous potential as a tool for patient-specific devices. This proof-of-concept study demonstrated the feasibility, antimicrobial properties, and computed tomography (CT) imaging characteristics of iodine/polyvinyl alcohol (PVA) 3D meshes and stents. Under scanning electron microscopy, cross-linked PVA displays smoother and more compacted filament arrangements. X-ray and transaxial CT images of iodized PVA vascular stents show excellent visibility and significantly higher Hounsfield units of radiopacity than control prints. Three-dimensional PVA prints stabilized by glutaraldehyde cross-linking and loaded with iodine through sublimation significantly suppressed Escherichia coli and Staphylococcus aureus growth in human blood agar disk diffusion assays. It is suggested that PVA 3D printing with iodine represents an important new synthetic platform for generating a wide variety of antimicrobial and high-visibility devices.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
Journal3D Printing and Additive Manufacturing
Volume5
Issue number1
DOIs
StatePublished - Mar 2018

Keywords

  • antimicrobials
  • computed tomography
  • iodinated contrast
  • personalized medicine
  • three-dimensional printing

Fingerprint

Dive into the research topics of 'Three-Dimensional Printing Antimicrobial and Radiopaque Constructs'. Together they form a unique fingerprint.

Cite this