Three-Dimensional Printing Antimicrobial and Radiopaque Constructs

Christen J. Boyer; David H. Ballard; Jeffery A. Weisman; Spencer Hurst; David J. McGee; David K. Mills; Jennifer E. Woerner; Uday Jammalamadaka; Karthik Tappa; Jonathan Steven Alexander

doi:10.1089/3dp.2017.0099

Three-Dimensional Printing Antimicrobial and Radiopaque Constructs

Christen J. Boyer, David H. Ballard, Jeffery A. Weisman, Spencer Hurst, David J. McGee, David K. Mills, Jennifer E. Woerner, Uday Jammalamadaka, Karthik Tappa, Jonathan Steven Alexander

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Three-dimensional (3D) printing holds tremendous potential as a tool for patient-specific devices. This proof-of-concept study demonstrated the feasibility, antimicrobial properties, and computed tomography (CT) imaging characteristics of iodine/polyvinyl alcohol (PVA) 3D meshes and stents. Under scanning electron microscopy, cross-linked PVA displays smoother and more compacted filament arrangements. X-ray and transaxial CT images of iodized PVA vascular stents show excellent visibility and significantly higher Hounsfield units of radiopacity than control prints. Three-dimensional PVA prints stabilized by glutaraldehyde cross-linking and loaded with iodine through sublimation significantly suppressed Escherichia coli and Staphylococcus aureus growth in human blood agar disk diffusion assays. It is suggested that PVA 3D printing with iodine represents an important new synthetic platform for generating a wide variety of antimicrobial and high-visibility devices.

Original language	English
Pages (from-to)	29-35
Number of pages	7
Journal	3D Printing and Additive Manufacturing
Volume	5
Issue number	1
DOIs	https://doi.org/10.1089/3dp.2017.0099
State	Published - Mar 2018

Keywords

antimicrobials
computed tomography
iodinated contrast
personalized medicine
three-dimensional printing

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title = "Three-Dimensional Printing Antimicrobial and Radiopaque Constructs",

abstract = "Three-dimensional (3D) printing holds tremendous potential as a tool for patient-specific devices. This proof-of-concept study demonstrated the feasibility, antimicrobial properties, and computed tomography (CT) imaging characteristics of iodine/polyvinyl alcohol (PVA) 3D meshes and stents. Under scanning electron microscopy, cross-linked PVA displays smoother and more compacted filament arrangements. X-ray and transaxial CT images of iodized PVA vascular stents show excellent visibility and significantly higher Hounsfield units of radiopacity than control prints. Three-dimensional PVA prints stabilized by glutaraldehyde cross-linking and loaded with iodine through sublimation significantly suppressed Escherichia coli and Staphylococcus aureus growth in human blood agar disk diffusion assays. It is suggested that PVA 3D printing with iodine represents an important new synthetic platform for generating a wide variety of antimicrobial and high-visibility devices.",

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author = "Boyer, {Christen J.} and Ballard, {David H.} and Weisman, {Jeffery A.} and Spencer Hurst and McGee, {David J.} and Mills, {David K.} and Woerner, {Jennifer E.} and Uday Jammalamadaka and Karthik Tappa and Alexander, {Jonathan Steven}",

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year = "2018",

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doi = "10.1089/3dp.2017.0099",

language = "English",

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AU - Ballard, David H.

AU - Weisman, Jeffery A.

AU - Hurst, Spencer

AU - McGee, David J.

AU - Mills, David K.

AU - Woerner, Jennifer E.

AU - Jammalamadaka, Uday

AU - Tappa, Karthik

AU - Alexander, Jonathan Steven

PY - 2018/3

Y1 - 2018/3

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AB - Three-dimensional (3D) printing holds tremendous potential as a tool for patient-specific devices. This proof-of-concept study demonstrated the feasibility, antimicrobial properties, and computed tomography (CT) imaging characteristics of iodine/polyvinyl alcohol (PVA) 3D meshes and stents. Under scanning electron microscopy, cross-linked PVA displays smoother and more compacted filament arrangements. X-ray and transaxial CT images of iodized PVA vascular stents show excellent visibility and significantly higher Hounsfield units of radiopacity than control prints. Three-dimensional PVA prints stabilized by glutaraldehyde cross-linking and loaded with iodine through sublimation significantly suppressed Escherichia coli and Staphylococcus aureus growth in human blood agar disk diffusion assays. It is suggested that PVA 3D printing with iodine represents an important new synthetic platform for generating a wide variety of antimicrobial and high-visibility devices.

KW - antimicrobials

KW - computed tomography

KW - iodinated contrast

KW - personalized medicine

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Three-Dimensional Printing Antimicrobial and Radiopaque Constructs

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Keywords

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